Pilot grant

 
 Oklahoma Center for
 Respiratory and Infectious  Diseases

  

Centers for Biomedical Re​search Excellence (CoBRE)
Call for Proposals
Phase 2 OCRID-CoBRE Projects and 2017-2018 Pilot Project Grants 
     The Oklahoma Center for Respiratory and Infectious Diseases (OCRID) invites applications for phase 2 OCRID-CoBRE projects and 2017-2018 Pilot Project Grants. The purpose of this Call for Proposals is to select the most promising projects to be included in the Phase 2 OCRID-CoBRE application, due on September 28, 2017. The Phase 2 projects will be multi-year projects with budgets in the range of $130 – 170k/yr. The selected projects will also be awarded a 2017-2018 pilot project grant, and a mentor team will be assembled to assist the proposal development of each project. Full-time faculty members at any rank (excluding postdoctoral fellows and research associates) at OSU, OUHSC, OU Norman or OMRF are eligible to apply. Previous recipients of OCRID pilot projects grants may reapply and a progress report must be included. Applicants must propose a project that fits into the central theme of the OCRID-CoBRE, i.e. infectious diseases of the respiratory system. Projects that can be developed into a R01-type proposal within 6 months (Phase 2 projects) and that use OCRID research cores (Animal Models Core, Immunopathology Core and Molecular Biology Core) are encouraged.
   
     Four to five projects will be selected and awarded 12-month pilot project grants at a level of $25,000 to $50,000. The CoBRE will fund $25,000 for all awarded projects and additional matching funds of $25,000 are committed from OSU CVHS for CVHS applicants, $25,000 from OSU Office of Vice President for Research for OSU non-CVHS applicants, or $10,000 from the OUHSC College of Pharmacy (COP) for COP applicants. 
 
*For OSU applicants, budgets should be $50,000 in direct costs only.
*For OUHSC applicants, budgets should be $35,000 for COP and $25,000 for non-COP in direct costs only. OUHSC has granted a blanket IDC waiver to OUHSC applicants.
*For other non-OSU applicants, budgets should be $25,000 (DC plus institutional IDC rate).
 
Important Dates:
Application deadline: 5 pm, January 16, 2017
Anticipated Start Date: July 1, 2017 for Pilot Project Grants and immediately after selection for the preparation of phase 2 CoBRE project proposal
Funding End Date: June 30, 2018 (Pilot project grant, no extension will be granted)
 
Application Submission:
     Applicants should submit a complete application (see format below) in a single PDF file to ocrid@okstate.edu with “OCRID Phase II Project Application” on the subject line. Questions should be directed to Dr. Lin Liu, OCRID Director (lin.liu@okstate.edu). 
 
Review:
     The proposals will be screened by an internal review committee depending on the number of applications received and evaluated by an external review committee, and approved by the External Advisory Committee and NIH based on their eligibility for CoBRE research support, project relevance to the CoBRE central theme, scientific merit of the projects, the potential for developing a R01-type proposal within 6 months, and the PI’s productivity and potential to become an independent NIH-funded investigator.
 
Proposal Preparation:
     Proposals must be typed, single spaced with minimum 1" margins top, bottom & sides, and using a font no less than 11 point, and must not exceed the page limitations as indicated below.
 
1. Please use PHS398 forms and instructions (http://grants.nih.gov/grants/funding/phs398/phs398.html) and only the following sections have to be submitted:
  • Face Page
  • Project Summary (Page 2) (<250 words): this may be used for OCIRD website.
  • Research Strategy Section (limit 5 pages)
2. In addition to the research proposal, the Research Strategy Section (5 pages) must include descriptions of the following:
  • Plan for developing a R01 type proposal within 6 months.
  • Whether and how your project will utilize the OCRID Research Cores (A list of Core services is provided at the end of this document)
  • For applicants who received a previous OCRID pilot project grant, one additional page progress report must be provided, including project progress, publications/abstracts/presentations and grants submitted or obtained due to the previous OCRID funding.
3. References (limit 1 page)
4. Vertebrate Animals (if applicable). Please follow new instructions (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-16-006.html) (no page limit)
5. Personnel, Budget & Justification (for pilot project)  
  • Use NIH budget Form Page 4: Detailed Budget for Initial Budget Period
  • Budget justification (limit 1 page)
  • Salary for faculty and equipment are NOT allowed. However, the effort levels (calendar months) committed to the project should be included 
6. Biosketch of PI, use new NIH format version D (https://grants.nih.gov/grants/forms/biosketch.htm) with a list of current, pending and completed grants. Please include annual direct costs and effort levels (calendar months) for all of the research projects.
 
Terms:
  • A selected project may be removed from Phase 2 CoBRE application if satisfactory progress is not made in the development of the proposal.
  • Awardees will be required to follow the timelines for developing phase 2 project proposals.
  • Awardees will be required to prepare a “personal mentoring/development plan” with his/her mentor team.  
  • Awardees will be required to attend OCRID meetings including proposal development, seminars, workin-progress and journal club and give a presentation at the Annual Respiratory and Infectious Diseases Research Retreat.
  • Awardees MUST acknowledge this grant support as well as CoBRE Research Core support (if applicable) in each publication, presentation, press release, or other document about research. A disclaimer should be included such as "Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM103648. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health." Prior to issuing a press release concerning the outcome of this research, please notify the NIH awarding IC in advance to allow for coordination.
  • Awardees must annually provide information on your publications, grants, awards, honors, special recognitions, and service in peer-review panels for the NIH progress report during the tenure of the CoBRE grant. 
 
DO NOT attach other materials to the proposal. Approvals for animal use and human subjects are not required at the time of submission. However, funds will not be released until proof of such approvals is presented.
 
Appendix: Services provided by OCRID-CoBRE Research Cores
 
Animal Models Core (AMC) (Director: Dr. Myron Hinsdale)
1. Colony management and husbandry
2. Optimizing genotyping of colony animals
3. Intranasal infection of animals
4. Pulmonary function tests (FlexiVent analyses of compliance, resistance etc….)
5. Blood gas analyses
6. Post-infection monitoring of animals
7. Animal dissections and tissue collections
8. Bronchioalveolar lavage fluid (BAL) collection
9. Intratracheal instillation of reagents (e.g. LPS, bacteria)
 
Immunopathology Core (IPC) (Director: Dr. Jerry Ritchey)
1. Support for research design with regard to pathology sampling needs
2. Tissue processing for paraffin-embedded tissue sections and routine stains.
3. Immunohistochemistry and immunofluorescence tissue staining.
4. Histological evaluation of tissues and lesion scoring.
5. Technical support for evaluations utilizing confocal microscopy and interpretation of images obtained by electron microscopy.
6. Support for Flow cytometry (4-color-capability).
7. Support for basic tests of immune function including tests of cell mediated immunity (intracellular cytokine staining utilizing flow cytometry), in vitro assays, quantitation of cytokine gene expression, or cytokine proteins (ELISA).
 
Molecular Biology Core (MBC) (Director: Dr. Lin Liu)
1. RNAi vectors and CRISPR/Cas9 for gene silencing and knockout.
2. Overexpression vectors for transgene expression.
3. Mutagenesis.
4. Gene and pathway reporter assays.
5. Support for efficient transfection using adenovirus and lentivirus vectors or the Amaxa system.
6. Real-time PCR gene qualification.
7. DNA microarray analyses and RNAseq.
8. Advice and consultation on various aspects of molecular biology to the COBRE and center investigators and develop or adopt new methods as needed.
Slideshow Title: 
Call for Proposal
Slideshow Subtitle: 
Funding Opportunities
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