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Oklahoma Center for
Respiratory and Infectious Diseases

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About Us
Messagefrom the Director
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CoBRE Phase I Projects 
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Animal Models Core  
Immunopathology Core 
Molecular Biology and Genomics Core 
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About Us
Messagefrom the Director
Organizational Chart 
Membership 
People
Leadershipand Administrative Staff
Advisory Boards 
Center Investigators  
Projects
CoBRE Phase I Projects 
CoBRE Phase II Projects 
Pilot Projects 
Core Facilities
Animal Models Core  
Immunopathology Core 
Molecular Biology and Genomics Core 
Activities
Seminars 
Symposium 
Donate News

 

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The OCRID 12th Annual Research Symposium was a huge success!

Special Thank You to Our Guests and Sponsors!
On April 8th OCRID hosted one of our best symposiums yet! We have to say a huge shout-out to our sponsors this year who helped make this an event to remember. 

OCRID 2025 Seminar Series is officially in full swing!

We are so excited to host this diverse group of speakers. 
Our next seminar will be Wednesday, April 30th at 12:00pm. 
 
All OCRID activities will be in McElroy Hall RJP 140 and available via zoom. For more information see the link below!

A message from our Director!

Welcome to the website of the Oklahoma Center for Respiratory and Infectious Diseases (OCRID) of Oklahoma State University (OSU).
Message from the Director

News

OCRID Investigators Ranked Among the Top 2% of Scientists by Stanford

4/25/2025

Congratulations to Dr. Jennifer Rudd on Medal for Excellence in Research University Teaching

03/10/2025

OCRID Center Investigator Dr. Clinton Jones elected as Fellow of the American Academy of Microbiology

02/24/2025

Spotlight on Dr. Rudragouda Channappanavar: Pioneering Research in SARS-CoV-2-Induced Lung Pathology

09/09/2024

OCRID Shines at the 9th National IDeA Symposium of Biomedical Research Excellence

7/30/2024

Three OCRID Faculty Honored with Excellence in Research Mentoring Award

6/10/2024

NIAID Releases H5N1 Influenza Research Agenda

6/5/2024

OCRID Mentor, Dr. Tyrrell Conway Leads New Microbiome Research Center at Oklahoma State University

5/20/2024

                                                                                                                                                                                                                                                                                                                                                                        More OCRID News

Get to Know Us!OCRID offers a variety of core services and we are working on some exciting projects. 

dr. lin liu at microscope
dr. lin liu at microscope
Molecular Biology Core - Molecular biology approaches are utilized to understand the mechanisms underlying respiratory diseases caused by respiratory pathogens. The overall objective of the Molecular Biology Core (MBC) is to provide centralized services and technical expertise in molecular biology for Phase III CoBRE and non-CoBRE investigators. Under the Phase I CoBRE award, the MBC was established to provide services involving molecular biology technologies, including RNAi gene silencing, transgene expression, mutagenesis, gene and pathway reporter assays, real-time PCR, and DNA microarray analyses for gene profiling. State-of-the-art technologies and other services based on the needs of the CoBRE investigators have been continuously developed and added to the Core since its inception. In Phase II, the MBC was expanded to include new techniques, including CRISPR/Cas9 technology and bulk RNA sequencing, and to offer reagents for respiratory and infectious disease research, including cell lines, primary lung cells, and respiratory viruses and bacteria. This Phase III application describes additional cutting-edge technologies and valuable reagents that will be offered to Center investigators, including single-cell RNA sequencing, spatial gene profiling, genome-wide CRISPR screening, human lung tissue models (lung organoids) and clinical samples from respiratory infectious disease patients. The specific aims of the MBC are to provide services and support for 1) functional studies using RNAi and CRISPR/Cas9, transgene overexpression, mutagenesis and deletion, lentiviral, adenoviral and nonviral vectors for gene transfer, and stable knockout and transgenic cell lines, 2) genome-wide gene profiling using bulk RNA sequencing, single-cell RNA sequencing, and spatial gene profiling, 3) genome-wide CRISPR gene activation, knockout and interference screens, 4) molecular assays including reporter assays, real-time PCR and droplet digital PCR, 5) reagents for respiratory and infectious disease research including respiratory viruses and bacteria, and reporter viruses, cell lines, primary lung cells, human lung organoids and clinical samples from respiratory infectious disease patients, and 6) advice, consultation and training on various aspects of molecular biology, developing or adapting new methods as needed and disseminating core resources and technologies. OCRID core facilities are committed to providing top quality services and technical expertise in respiratory and infectious disease for center investigators as well as non-center investigators.
dr. myron hinsdale with lab gel
dr. myron hinsdale with lab gel
Animal Model Core - Pilot project investigators, OCRID faculty, and other Oklahoma investigators may have limited animal research experience and limited biosafety level training in in vivo preclinical experimentation of respiratory and infectious diseases. In addition, these researchers will need in vivo validation of in vitro discoveries. As a result, consistent care, experimental procedures with pathogens in vivo, and animal husbandry are important for the success of the pilot projects, funding applications, and manuscript publication. Therefore, the objective of the Animal Models Core (AMC) is to ensure experimental consistency, compliance with animal welfare and pathogen safety regulations, and to provide training in animal model phenotyping and cutting-edge respiratory and infectious disease experiments. OCRID core facilities are committed to providing top quality services and technical expertise in respiratory and infectious disease for center investigators as well as non-center investigators.The image attribution
photo of the flow cytometry lab
photo of the flow cytometry lab
Immunopathology Core - The Immunopathology Core (IPC) provides state-of-the-art diagnostic pathology and immunology services to COBRE and other OCRID investigators. Biomedical researchers are often limited in performing complex immunopathologic analyses due to a lack of available technology/instrumentation, or by inexperience in delineating complex mechanisms associated with immune dysfunction and disease pathogenesis. These limitations highlight a critical need for a centralized resource by which investigators can receive collaborative and/or technical support necessary for their project’s success. The IPC provides (1) access to cutting-edge assays for immunological data curation, (2) tissue processing for histopathology and downstream immunologic assays, and (3) expert support in analyses of immunopathologic data and gross/histologic lesion interpretation. COBRE funds in Phases I-II focused on establishing, expanding, and upgrading the IPC equipment and services available to researchers. Substantial growth in Phase II highlighted the critical role of the IPC in the OCRID research infrastructure. In July 2023, the IPC was awarded Phase III funding and will focus on expanding the IPC into a self-sustaining entity able to support current and long-term state-of-the art research projects at local and regional institutions. OCRID Core facilities are committed to providing top quality services and technical expertise in respiratory and infectious disease for center and non-center investigators.
Headshot of Dr. Gabriel Cook
Headshot of Dr. Gabriel Cook
Pilot Project Leader: Dr. Gabriel Cook, Ph.D., Oklahoma State University - CAS ... Pilot Project: Glycosylation and Structural Studies of SARS-CoV-2 Entry Membrane Protein TMPRSS2
Headshot of Dr. Jennifer Rudd
Headshot of Dr. Jennifer Rudd
Pilot Project Leader: Dr. Jennifer Rudd, Ph.D., Oklahoma State University - CVM ... Pilot Project: siRNA-mediated gene silencing to identify functional NETosis pathways in a feline model for COVID-19
Headshot of Dr. Susan Schroeder
Headshot of Dr. Susan Schroeder
Pilot Project Leader: Dr. Susan Schroeder, Ph.D., The University of Oklahoma - CAS ... Pilot Project: DRS to Identify Epitranscriptomic Changes in Response to Influenza and Smoking
Dr. Sunil More
Dr. Sunil More
Pilot Project Leader: Dr. Sunil More, Ph.D., Oklahoma State University - CVM ... Pilot Project: Interferon-Mediated Impairment in Macrophage Antibacterial Activity during SARS-CoV-2 and Klebsiella pneumoniae Co-Infection
Headshot of Dr. Reed Stubbendieck
Headshot of Dr. Reed Stubbendieck
Pilot Project Leader: Dr. Reed Stubbendieck, Ph.D., Oklahoma State University - CAS ... Pilot Project: Identification of Antimicrobial Peptides against S. aureus produced by D. pigrum in the Nose
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