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A message from our Director! 

Welcome to the website of the Oklahoma Center for Respiratory and Infectious Diseases (OCRID) of Oklahoma State University (OSU).
Message from the Director

OCRID Receives 5.5 million NIH Phase III CoBRE Funding

We are so pleased to announce that the Oklahoma Center for Respiratory and Infectious Diseases (OCRID) has received the Notice of Award for our Phase III CoBRE application. With this award OCRID completes a “firsts” hat-trick at Oklahoma State University (OSU). OCRID was the first CoBRE grant awarded to OSU, the first CoBRE grant moved to Phase II, and finally the first CoBRE grant moved to Phase III. We are excited to continue and expand on all the great opportunities that 10 years of OCRID has brought to Oklahoma.
Full News Article

OCRID 2023-2024 Call for Proposals

The Oklahoma Center for Respiratory and Infectious Diseases (OCRID) invites applications for Pilot Project Grants. The purpose of the pilot project grant program is to provide seed funding to generate preliminary data for an extramural research grant application.
 
Important Dates:
Application deadline: 5:00 pm, August 1, 2023
Anticipated Start Date: November 1, 2023
Funding End Date: June 30, 2024 (no extension will be granted)
More Information

 

News

OCRID Pilot Project Leader Awarded National Science Foundation Grant

09/13/2023

Dr. Jennifer A. Philips, MD, PhD of the Washington University School of Medicine to Join OCRID External Advisory Committee

09/05/2023

OCRID Receives 5.5 million NIH Phase III CoBRE Funding

7/27/2023

OCRID Project Leader Awarded Cystic Fibrosis Foundation Grant

7/27/2023

OCRID Pilot Project Leader Awarded USDA-NIFA Grant

12/15/2022

OCRID Pilot Project Leader Obtains 2 R01s!

11/07/2022

Collaboration landed two NIH grants totaling 3.4 million 

11/07/2022

OCRID Mentor Dr. Tyrell Conway Working with Swiss Team Makes Health Breakthrough

5/18/2022

                                                                                                                                                                                                                                                                                                                                                                        More OCRID News

Get to Know Us!OCRID offers a variety of core services and we are working on some exciting projects. 

dr. lin liu at microscope
dr. lin liu at microscope
Molecular Biology Core - Molecular biology approaches are utilized to understand the molecular mechanisms of respiratory diseases caused by respiratory pathogens, including, not limited to influenza virus, SARS-CoV-2, RSV, Streptococcus pneumoniae and Pseudomonas aeruginosa. The overall objective of the Molecular Biology Core (MBC) is to provide centralized services and technical expertise in molecular biology for CoBRE project investigators, pilot project investigators, and other investigators. The specific aims of the MBC are to provide services and support for 1) functional studies using RNAi and CRISPR/Cas9, transgene overexpression, and mutagenesis/deletion, 2) genome-wide gene profiling using RNA sequencing, 3) molecular assays including reporter assays and real-time quantitative PCR, 4) reagents for respiratory and infectious disease research including primary lung cells, respiratory viruses and bacteria, and 5) advice, consultation and training on various aspects of molecular biology and developing or adopting new methods as needed.  
dr. myron hinsdale with lab gel
dr. myron hinsdale with lab gel
Animal Model Core - The broad and long term goal of the Animal Models Core is to provide consistent care, experimental procedures, and husbandry that are important to the success of projects. Each promising investigator has limited animal experimental experience, but needs to verify in vitro findings in vivo. Therefore, the Animal Model Core (AMC) will ensure project experimental consistency, compliance with federal animal welfare regulations, and effective training of project leaders and personnel in animal experimentation. Dr. Hinsdale will serve as the AMC director, and along with technical staff, will provide basic services (e.g. Colony management and husbandry, biosafety containment and housing of animals, infection of animals and harvesting of samples for analysis, and pulmonary function tests). The current experimental animal models will be mice. The four projects that are proposed require mice to further verify in vivo findings arising from the proposed in vitro experiments. In project 1, using some remarkable viral strains, BALB/c mice will be used to determine the role of the human Respiratory Syncytial Virus (RSV) Matrix protein in viral infection. In project 2, influenza infected mice will be used to validate important host factors in an innovative in vitro respiratory model. In project 3, using a novel mouse model of acute lung injury, challenged mice will be used to mechanistically explore the exciting and potential therapeutic role of a unique protein on acute bacterial lung injury. In project 4, mice will be used to determine mechanistically the pathogenic role that specific chemokine and cytokine mediators have in acute lung injury due to influenza and to determine the pioneering therapeutic combinations for ameliorating this acute lung injury. In all, the up-and-coming young investigators of this application will be breaking new ground in pulmonary disease and gaining important animal model training to prepare them for promising independent research careers.The image attribution
Dr. Jerry Ritchey with microscope
Dr. Jerry Ritchey with microscope
Immunopathology Core - The specific aim of the Immunopathology Core Program (IPC) is to provide pathology and immunology support to COBRE and other Oklahoma Center for Respiratory and Infectious Diseases (OCRID) investigators. Services provided by the IPC include a broad range of pathology support including gross necropsy and tissue collection, tissue processing, sectioning of either frozen or paraffin-embedded tissues, routine and special stains, immunohistochemistry (IHC), immunofluorescence (IFC), and coordination of ancillary services (clinical pathology, bacteriology, virology, toxicology). Immune responses important in the development of disease are characterized by evaluation of cell-mediated immunity (ELISPOT, flow cytometry for intracellular IFNγ) and phenotypic identification of inflammatory cells within lesions (IFC, IHC, flow cytometry). The IPC will also coordinate with the Animal Models Core (AMC) and Molecular Biology Core (MBC) to assist investigators with humoral immunity (serology, ELISA) and quantitation of cytokine gene expression (real-time PCR) respectively. To achieve this aim, the IPC is staffed by three board-certified pathologists with experience in animal models and respiratory/infectious disease research and will recruit an experienced, extensively cross-trained technician. The IPC has the resources in place to serve as the foundation and a strong institutional commitment to ensure development of the IPC into a self-sustaining facility integral to the research infrastructure of OCRID.
dr. craig miller
dr. craig miller
Dr. Craig Miller, Oklahoma State University - CVM, is heading up a brand new 2-year OCRID Project entitled: Validation of a naturally-occurring animal model for SARS-CoV-2 infection.
Dr. Joshua Butcher
Dr. Joshua Butcher
Dr. Joshua Butcher, Ph.D., Oklahoma State University - CVM - Determining the Cellular Mechanisms Whereby Skeletal Muscle (Fiber Type) Prevents Influenza-Induced Mortality in Sarcopenic Obesity
Dr. Anthony Burgett
Dr. Anthony Burgett
Dr. Anthony Burgett, The University of Oklahoma Health Science Center - CoP, is heading up a new Pilot Project entitled: Drug Targeting of Oxysterol-Binding Protein (OSBP) for Respiratory Viral Infections
Dr. Avi Mitra
Dr. Avi Mitra
Dr. Avi Mitra, Oklahoma State University-CAS, is heading up a new Pilot Project entitled: Molecular Components of the two heme uptake pathways of mycobacterium tuberculosis
Dr. Sunil More
Dr. Sunil More
Dr. Sunil More, Oklahoma State University - CVM, is heading up a new Pilot Project entitled: Pathogenesis of SARS-CoV-2 and Klebsiella Pneumoniae coinfection
Dr. Yong Cheng
Dr. Yong Cheng
Dr. Yong Cheng, Oklahoma State University - DASNR, is heading up a new Research Project entitled: Understanding the Mechanism of Immune Dysfunction in a Cystic Fibrosis Murine Model During Non-tuberculous Mycobacterial Infection
This is alt text for the image
This is alt text for the image
Dr. Marianna Patrauchan, Oklahoma State University - CAS, heads up a Research Project entitled: Two Pathways for Calcium Signaling and Virulence Regulation in P. aeruginosa
Dr. Veronique Lacombe
Dr. Veronique Lacombe
Dr. Veronique Lacombe, Oklahoma State University - CVM, heads up a Research Project entitled: The Role of Glucose Homeostasis During Respiratory Infections
Dr. Rudra Channappanavar
Dr. Rudra Channappanavar
Dr. Rudra Channappanavar, Oklahoma State University - CVM, is heading up a new Research Project entitled: Iflammatory monocyte-macrophages in age-related susceptibility to SARS-CoV-2 infection
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