Center Investigators

Gillian M. Air, Ph.D.

George Lynn Cross Research Professor and Interim Chair,
Biochemistry and Molecular Biology,
Associate Dean, Graduate College
University of Oklahoma Health Sciences Center-Oklahoma City
 
Contact Information:
Email: gillian-air@ouhsc.edu
Phone: (405) 271-2227 ext. 61250
Office: Rm 853, Biomedical Sciences Building
             940 Stanton L. Young, Oklahoma City, OK 73104
           
 
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Research Interests:
My expertise is in molecular and biochemical aspects of influenza. Our research had two branches, one to find ways of designing better vaccines, and the second to investigate how the virus gains entry into cells and how infection might be blocked by antiviral drugs.
Using monoclonal antibodies, we determined the extent and nature of epitopes on the two major surface antigens in influenza virus, hemagglutinin and neuraminidase, studying how antibodies bind to these to inhibit activity and hence virus spread, and how the virus can mutate to escape from neutralizing antibodies. We applied these results to analyze the quality as well as quantity of antibodies present in human sera after influenza vaccination and we showed that study of the fine specificities of antibodies in people who have been vaccinated or infected with influenza might predict the direction of antigenic drift, which would allow formulation of vaccines ahead of the epidemic.
We were also involved in projects to design new NA inhibitors, and to identify receptors on the cell surface that facilitate virus infection with the idea of blocking that process with new drugs. It has been known for many years that the primary receptor for influenza is sialic acid, but our recent work showed that the pattern of recognition for sialic acids and their neighboring sugars is more complex than originally thought. There is year-to-year variation in the binding profile to an array of synthetic sialylated glycans. We think this is a consequence of the mutations that drive antigenic drift and that specific glycan structures are not needed for influenza infection.

 

 

Shanjana Awasthi, Ph.D

Associate Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center
Oklahoma City

Contact Information
Phone: (405) 271-6593 
Office: Rm 324 College of Pharmacy Building
             1110 N StonewallOklahoma City, OK 73117
 
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Research Interests:
Research in my lab is focused on developing immunotherapeutics and vaccines by harnessing our body's natural host defense mechanisms. Our research efforts have been focused on developing TLR4- interacting surfactant protein-A-derived peptides and dendritic cell-based vaccine approaches. We are interested in investigating the mechanism and efficacy of these approaches in vitro and in animal models of infection, inflammation and cancer.
 

 

Melanie A. Breshears, Ph.D.

Professor, Anatomic Pathology
Department of Veterinary Pathobiology
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater
 
Contact Information:
E-mail: melanie.breshears@okstate.edu
Phone: (405) 744-4463
Office: Rm 260A McElroy Hall
          Stillwater, OK 74078 
 
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Research Interests:
Research Interests:
My collaborative research interests involve providing pathology support for projects studying a wide range of diseases, including the following:
  • Bdellovibrio bacteriovorus as an experimental treatment for bovine infectious keratoconjunctivitis (P.I.-M. Boileau)
  • Pathogen vector interactions of Anaplasma phagocytophilum and Ixodes scapularis in sheep (P.I.- K. Kocan); Tissue based host cell for A. phagocytophilum infection of ticks (P.I.- E. Reppert)
  • Spectroscopy for evaluation of intervertebral disc mineralization in dogs (P.I.- D. Piao & K. McKeirnan)
  • Evaluation of effects of voriconazole injection on the equine cornea (P.I.- K. Smith & M. Gilmour)
  • microRNA effects of hyperoxia exposure on neonatal lungs (P.I.- L. Liu)
  • Effect of season on histological appearance of the equine pituitary gland (P.I.- D. McFarlane)

Stephen Clarke, Ph.D.

Associate Professor
Nutritional Sciences
College of Human Sciences
Oklahoma State University
Stillwater

Contact Information:
Email: stephen.clarke@okstate.edu
Phone: 405-744-2033
Office: 417 Human Sciences
Stillwater, OK 74078

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Education   Academic Appointments   Awards and Honors
Other Professional Memberships   Research Funding   Selected Publications

Research Interests:
The goal of my current work is to better understand the molecular causes of symptoms associated with iron deficiency. My team is examining the microRNA profile of tissues that are central to maintaining normal iron homeostasis, and we have started to characterize the targets of iron-regulated microRNA. In slightly more applied research, I continue to collaborate with Drs. Lucas, Smith and Stoecker to assess the extent to which iron status affects an individual's risk of developing osteoporosis. Finally, more recently I have started to examine the role that iron plays in contributing to neurodegenerative diseases such as Alzheimer's or Parkinson's disease.

Mark Coggeshall, Ph.D.

Robert S. Kerr, Jr. Endowed Chair,
Oklahoma Medical Research Foundation
 
Contach Information:
Phone: (405) 271-7905
Office: Rm 23 Multiple Sclerosis Center
          Oklahoma Medical Research Foundation,
          Oklahoma City, OK 73104
 
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Research Interests:
We investigate mechanisms leading to microvascular dysfunction, complement activation and coagulopathic responses to S. aureus and B. anthracis. We discovered the proinflammatory effects of peptidoglycan in human immune cells, identified the cells that responded and the mechanism by which they respond. The latter includes the novel finding that IgG facilitates Fc -mediated peptidoglycan phagocytosis and lysosomal digestion to create NOD ligands, and platelet activation by FcγRIIa and complement. In signaling, we were the first to show that PLCγ activation is central to lymphocyte antigen and Fc receptor signaling, that a Src-family kinase links these receptors to PLCγ activation, and that signaling events in immune cells are regulated by FcγRII recruitment of the inositol phosphatase SHIP. Our laboratory is heavily invested in phospho-flow, flow cytometry and confocal microscopy to quantitate the stimulation of intracellular events and how they are influenced by bacterial pathogens  and cytokines. We showed that peptidoglycan is a common, shared, and central Gram-positive pathogen associated molecular pattern that contributes to the pathology of sepsis and that the presence of anti-peptidoglycan antibodies are needed for the responses. We discovered that peptidoglycan activates the classical complement pathway and that complement activation was removed after depletion of anti-peptidoglycan antibodies, indicating input from the classical pathway. Peptidoglycan stimulated human platelets to aggregate via platelet FcyRIIa through the peptidoglycananti-peptidoglycan immune complexes and through the complement products. In addition, we discovered the in vivo pathology caused by peptidoglycan infusion: vascular leakage, evidence of disseminated intravascular coagulation, and organ failure, all accompanied by complement deposition. I have long experience overseeing research of the type proposed here, and in guiding projects as they evolve in different directions. I have been the PI on a U19 multi-project grant focused on pathobiology of anthrax. The work involves successful and sustained collaborations with researchers in several foreign institutions, as are required by the project proposed here. 

Anthony W. Confer, Ph.D., D.V.M.

Regents Professor & Sitlington Endowed Chair,
Department of Veterinary Pathology
Center for Veterinary Health Sciences,
Oklahoma State University-Stillwater

Contact Information:
E-mail: anthony.confer@okstate.edu
Phone: (405) 271-7905
Office: Rm 250 McElroy Hall
Stillwater, OK 74078

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Education    Academic Appointments    Awards and Honors
Research Funding    Selected Publications    Patents

Research Interests:
Major research interests are in bovine respiratory disease pathogenesis and immunity especially related to Mannheimia haemolytica and Pasteurella multocida infections. Our laboratory is currently focused on the role of outer membrane and secreted proteins in mucosal and systemic immunity against cattle bacterial pneumonia.

Michael Scott Davis, DVM, PhD

Professor and Endowed Chair,
Department of Physiological Sciences
Center for Veterinary Health Sciences,
Oklahoma State University-Stillwater
 
Contact Information:
Phone: (405) 744-8172
Office: Rm 264 McElroy Hall
           Stillwater, OK 74078
 
 
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Research Interests:
Exercise physiology and pathophysiology, including the effects of exercise on respiratory function

 

Junpeng Deng, Ph.D.

Professor,
Department of Biochemistry and Molecular Biology,
Division of Agricultural Sciences and Natural Resources,
Oklahoma State University-Stillwater

Contact Information:
E-mail: junpeng.deng@okstate.edu
Phone: 405-744-6192
Office: Rm 120D Henry Belmont Research Center
          Stillwater, OK 74078

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Other Professional Memberships    Research Funding     Selected Publications

Research Interests:

Structure-function studies on poxvirus membrane biogenesis and immune evasion. Poxviruses include some dangerous emerging or re-emerging pathogens as well as some promising vaccine vectors for infectious diseases and cancers. They are unique among viruses in that they encode a large number of proteins that are dedicated to evading host immune responses. These proteins include secreted inhibitors of cytokines as well as intracellular inhibitors of immune signaling or antiviral factors. Structure and function study on the cytokine inhibitors is one of the major aims in this lab. Enveloped viruses typically acquire their outer lipid bilayer by budding from cellular membranes, a process that is similar to the formation of cellular transport vesicles. Poxviruses, however, are unusual in that their primary envelope is not acquired by budding but through extending of open-ended crescent membranes. The origin and biogenesis of the crescent membranes are among the least understood aspects of poxvirus biology. Recent studies suggest that the crescents may derive from the endoplasmic reticulum (ER). At least five VACV proteins (A6, A11, A30.5, H7 and L2), collectively termed viral membrane assembly proteins (VMAPs) and conserved in all vertebrate poxviruses, have been found to be essential for the biogenesis of crescent membranes. VACV mutants deficient in VMAPs make viroplasms but fails to form crescents. We discovered VACV A6 as a key member of VMAPs and suggested that viral membranes are trafficked from ER to ‘viral factories’ through an active, A6-mediated process. Our recent results led us to the innovative hypotheses that A6 is a novel lipid-transfer protein (LTP) and that poxviruses obtain their primary envelope by mimicking or hijacking the cellular LTP-mediated nonvesicular lipid transport process. To our knowledge, LTP has not been previously identified in any viruses, and nonvesicular lipid transport is not known to play a role in viral replication. Detailed structure and function studies on poxvirus membrane biogenesis are currently being actively pursued.

 

Adam S. Duerfeldt, Ph.D.

Assistant Professor
Department of Chemistry & Biochemistry
Institute for Natural Products Applications & Research Technologies (INPART)
University of Oklahoma
Norman, OK

Contact Information:
E-mail: adam.duerfeldt@ou.edu
Phone: 405-325-2232
Office: 101 Stephenson Parkway SLSRC 2130
Norman, OK 73019

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Selected Publications

Research Interests:
We are a highly collaborative medicinal chemistry team focused on 1) the development of chemical tools that can be utilized to enhance our understanding of disease mechanisms and 2) the development of new therapeutic leads for the treatment of cancers, bacterial infections, and ocular diseases. Our approach integrates synthetic chemistry, chemical and structural biology, and computational methods to provide innovative solutions to important scientific problems.

 

 

Richard Eberle, Ph.D.

Professor
Department of Veterinary Pathobiology
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater

Contact Information:
E-mail: r.eberle@okstate.edu
Phone: (405) 744-8169
Office: 250 McElroy Hall
Stillwater, OK 74078

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Research Funding    Selected Publications

Research Interests:

Molecular biology of simian herpesviruses, anti-viral drug therapy for zoonotic monkey B virus infections, molecular basis for differential neurovirulence of simian herpesviruses

 

Yu Feng, Ph.D.

Assistant Professor
Department of Chemical Engineering
Oklahoma State University

Contact Information:
E-mail: yu.feng@okstate.edu
Phone:
Office: 420 Engineering North
Stillwater, OK, 74078

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Other Professional Memberships    Research Funding Selected Publications

Research Interests:
Dr. Yu Feng joined the School of Chemical Engineering at Oklahoma State University as an Assistant Professor in August 2016. He also joined the Oklahoma Center for Respiratory and Infectious Diseases (OCRID) as an investigator. Yu Feng was a Research Assistant Professor and Lab Manager of the Computational Multi-Physics Laboratory (CM-PL) at North Carolina State University. He has also held an affiliation with DoD Biotechnology HPC Software Applications Institute (BHSAI) as a Research Scientist II. He completed his B.S. in Engineering Mechanics in 2007 from the School of Aeronautics and Astronautics, Zhejiang University, Hangzhou, China. He then joined the Department of Mechanical and Aerospace Engineering at North Carolina State University and obtained his M.S. and Ph.D. degrees in 2010 and 2013 respectively. His current research interests include advanced computational fluid-particle dynamics (CF-PD) modeling for the transport and deposition of inhalable drugs and toxicants in human respiratory systems, with applications of medical device improvements for effective and targeted drug deliveries, novel lung therapeutics, non-invasive disease diagnostic methodologies, and exposure health risk evaluations. The overall goal the research is to understand and consider more underlying physics and chemistry, in order to provide non-invasive, cost-effective, and accurate numerical tools with more simulating capabilities, complementing in vitro and in vivo studies for interdisciplinary engineering practice and academic research.

Ashlee N. Ford Versypt, Ph.D.

Assistant Professor
School of Chemical Engineering
College of Engineering, Architecture and Technology
Oklahoma State University-Stillwater

Contact Information:
E-mail: ashleefv@okstate.edu
Phone: (405)744-5280 
Office: Rm 420, Engineering North,
Stillwater, OK 74078

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Education    Academic Appointments    Awards and Honors
Research Support  Selected Publications

Research Interests: Systems Biomedicine & Pharmaceutics
Mathematical & Computational Modeling
Drug Delivery
Physiology

 

Heather Gappa-Fahlenkamp, Ph.D.

Associate Professor
School of Chemical Engineering
College of Engineering and Architecture Technology
Oklahoma State University-Stillwater

Contact:
Phone(405) 744-5280
Office423 Engineering North
             Stillwater, OK 74074
 
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Research Interests:
Tissue Engineering: Advanced Tissue-Equivalent Models to Study Inflammation Associated with Vascular Complications, Allergens, and Infectious Agents. Drug Delivery: Nanoparticles and Biomembranes for Controlled Delivery
 

Lucila Garcia-Contreras, Ph.D.

Assistant Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center-Oklahoma City

Contact Information:
E-mail: lucila-garcia-contreras@ouhsc.edu
Phone: (405) 271-6593 ext. 47205
Office: Rm 321 College of Pharmacy Building
University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117

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Education    Academic Appointments     Awards and Honors
Other Professional Memberships    Research Funding    Selected Publications

Research Interests:
My expertise is in the design, formulation and evaluation of targeted drug delivery systems. Shortly after graduation from Pharmacy school I worked for 2 large pharmaceutical companies in their quality control department, while teaching Pharmaceutics at the National University in Mexico. From those earlier years in my career, I acquired a strong background and experience in the manufacturing and testing of pharmaceutical dosage forms as well as regulatory requirements, such as those by FDA. After graduate and postgraduate training in the United States in pharmacokinetics and formulation, my research has focused on the design, formulation and evaluation of inhaled drugs and vaccines in powder form to treat and prevent diseases such as asthma, tuberculosis, influenza, hepatitis B, diphtheria and diabetes for the past 12 years has focused on the design, formulation and evaluation of drugs and vaccines delivered by the pulmonary route for local and systemic action to treat and prevent diseases such as asthma, tuberculosis, influenza, hepatitis B, diphtheria and diabetes. I have designed and formulated drugs and vaccines into stable aerosol formulations for optimal delivery to laboratory animals and humans. A large part of my research has been devoted to the development of novel drug and vaccine formulations for the treatment and prevention of tuberculosis. My research pulmonary drug delivery has generated interest nationally and internationally while resulting in a number of peer-reviewed articles in high impact journals, invitations to organize and speak at international conferences and consult for small pharmaceutical companies.
At the OUHSC College of Pharmacy I have collaborated with other researchers in designing delivery systems and formulations to enhance the efficacy of their novel anti-cancer and vaccine drugs. I also plan to advance the current knowledge of pulmonary drug delivery by understanding the mechanisms of drug absorption and transport in different regions of the lung. I have always enjoyed teaching and I believe that my expertise and research program will be of interest and application to the studies and coursework of professional and graduate students.

 

William Hildebrand, Ph.D.

Robert Glenn Rapp Presidential Professor
Director, HLA Sequence-Based Typing Laboratory,
Department of Microbiology and Immunology, 
University of Oklahoma Health Sciences Center-Oklahoma City
 
Contact Information:
Phone: 405-271-1203
Office: Rm 317, Stanton L Young Biomedical Research Cntr 975 NE 10th St, Oklahoma City, Ok 73104

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Education    Academic Appointment    Awards and Honors
Other Professional Memberships    Research Support     Selected Publication

Research Support:

The Hildebrand Laboratory is focused on the major histocompatibility complex (MHC) class I and class II molecules. These molecules mediate the rejection of organ and bone marrow transplants, the targeting of cancerous and virus-infected cells for immune destruction and autoimmune responses such as diabetes and arthritis. To delineate the role that MHC molecules play in these various immune scenarios, the Hildebrand Laboratory studies MHC genes and the proteins they encode.

 

Myron Hinsdale, Ph.D.: Animal Model Core

Associate Professor
Department of Physiological Sciences
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater

Contact Information:
E-mail: myron.hinsdale@okstate.edu
Phone: (405) 744-8107
Office: Rm 264, McElroy Hall
            Stillwater, OK 74078

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Research Interests:

The objective for the Animal Models Core (AMC) is to ensure project experimental consistency, compliance with federal animal welfare regulations, and assistance in cutting-edge phenotyping of animal models of respiratory disease.  The AMC has a wide range of phenotyping strategies in respiratory disease animal models. We are interested in developing new models that can benefit the Respiratory Center. Specifically, our research program is interested in the influences of extracellular matrix on organ homeostasis. We are concentrating on the role extracellular matrix has under disease conditions and specifically in regards to influences of ECM proteins on cell signaling. We are focusing on epithelial tissue in organs including the kidney, liver, and lung with a special interest in endothelium. Using a novel mouse model of reduced ECM proteoglycans, our studies are focused on the role that ECM proteoglycans have on the reparative response subsequent to tissue damage and disease especially in COPD and polycystic kidney disease. Our group has a broad background in pathology, animal models, and genetics, and we have extensive experience in animal surgeries and physiological assessment of metabolism. 

Wouter Hoff
Associate Professor
Microbiology and Molecular Genetics
Oklahoma State University
 
2013-2014 Pilot Project 4: Photoreceptors as a Novel Class Virulence Factors in Opportunistic Pathogens
 
Contact Information:
Phone: 405-744-4449
Office: 307 Life Sciences East
Stillwater, OK 74078
 
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Alamdar Hussian, Ph.D.

Assistant Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center-Oklahoma City

Contact Information:
Phone: (405) 271-6593  ext. 47472
Office: Rm 316, College of Pharmacy Building
             1110 N Stonewall, Oklahoma City, Ok 73117

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Haobo Jiang, Ph.D.

Regents Professor, Department of Entomology and Plant Pathology,
Division of Agricultural Sciences and Natural Resources
Oklahoma State University-Stillwater

Contact Information:
E-mail: haobo.jiang@okstate.edu
Phone: 405-744-5527
Office: Rm 127 Noble Research Center
Stillwater, OK 74078

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Education    Academic Appointments    Awards and Honors
Other Professional Memberships    Research Funding    Selected Publications

Research Interests:
We have been investigating the molecular mechanisms of insect immune responses against pathogens that cause serious human diseases. Recognition of pathogens leads to the activation of a serine protease system in a cascade mode, which activates phenoloxidases and cytokines. Phenoloxidases generate reactive compounds to kill and sequester the invading organisms whereas cytokines trigger intracellular signaling pathways to induce the expression of antimicrobial peptides that destroy the infectious agents. We are examining the serine protease pathways and their regulation by serpins in a biochemical model insect, Manduca sexta, and trying to understand the similar system in Anopheles gambiae, the African malaria mosquito.

 

Gilbert John

Associate Professor
Microbiology and Molecular Genetics
Oklahoma State University 
 
Contact Information:
Phone: 405-744-7914
Office: 307 Life Sciences East
Stillwater, OK 74078
 
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Clinton Jones, Ph.D.

Sitlington Professor of Infectious Diseases
Oklahoma State University
Center for Veterinary Health Sciences
Department of Veterinary Pathobiology

Contact Information:
Email:  clint.jones10@okstate.edu
Phone:  405-744-1842
Office: RM 157C
McElroy Hall
Stillwater, OK 74078

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Education    Academic Appointments    Honors and Awards
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Susan Kovats, Ph.D.

Associate Member
Arthritis & Clinical Immunology Research Program
Oklahoma Medical Research Foundation-Oklahoma City
 
Contact Information:
Phone: (405) 271-8583
Office: Rm A207.3          
             Oklahoma City, OK 73104
 
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Sadagopan Krishnan

Assistant Professor,
Department of Chemistry,
College of Arts and Sciences
Oklahoma State University,

Contact Information:
Stillwater, OK, USA - 74078.
Phone: 405-744-5946
E-mail: gopan.krishnan@okstate.edu
Group Website: http://krishnangroup.okstate.edu

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Education    Appointments    Honors and Awards    Research Support

Research Interests:
Clinical Biosensors, Point-of-care methods, Biocatalysis, Biomarker validation, Novel Drug-screening arrays, Bioelectrochemistry, and Biological fuel-cells

Véronique A. Lacombe, Ph.D.

Associate Professor
Department of Physiological Sciences
Center for Veterinary Health Sciences
Oklahoma State University- Stillwater

Contact Information:
E-mail: veronique.lacombe@okstate.edu
Phone: (405) 744-8089
Office: Rm 283, McElroy Hall
Stillwater, Ok 74078

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Research Interests: 
Metabolism, Diabetes, Insulin resistance, Striated muscle, Comparative medicine

Shitao Li, Ph.D.

Assistant Professor
Department of Physiological Sciences
Center for Veterinary and Health Sciences
Oklahoma State University-Stillwater

Contact Information:
E-mail: shitao.li@okstate.edu
Phone: (405) 744-2158
Office: Rm 157B, McElroy Hall
Stillwater, OK 74078

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Education    Academic Appointments     Awards and Honors
Research Support     Selected Publications

Research Interests:
Innate immunity; Host defense and influenza A virus; Ubiquitination; Inflammation and TNF signaling; MicroRNA.

Dingbo Daniel Lin, Ph.D.

Assistant Professor
Department of Nutritional Sciences
Oklahoma State University

Contact Information:
Email: dingbo.lin@okstate.edu
Phone: 405-744-5215 (Office)
Fax: 405-744-1357
Office: 419 Human Sciences
Stillwater, OK 74078

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Lin Liu, Ph.D.

Regents Professor of Physiological Sciences
Lundberg-Kienlen Endowed Chair in Biomedical Research
Director, Oklahoma Center for Respiratory and Infectious Diseases
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater 
 
Contact Information:
Phone: (405) 744-4526
Office: 210 McElroy Hall, Stillwater, OK 74078
 
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Research Areas:
Host factors and influenza virus and bacterial infections; stem cell-based therapy; lung development, injury and repair; microRNAs; and pulmonary diseases (COPD, IPF, ARDS and BPD).

 

Pamela Lloyd, Ph.D.

Associate Professor
Department of Physiological Sciences
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater

Contact Information:
E-mail: pamela.lloyd@okstate.edu
Phone: (405) 744-9019
Office: Rm 269 McElroy Hall
            Stillwater, OK, 74078

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Other Professional Memberships    Research Funding    Selected Publications

Research Areas:
Mechanisms of blood vessel growth and repair; effect of metabolic conditions on collateral artery remodeling; regulation of vascular growth factors by shear stress and reactive oxygen species; endothelial function in chronic lung disease

Erika Lutter

Department for Microbiology and Molecular Genetics
Assistant Professor
Oklahoma State University
 
Contact Information: 
Phone: 405-744-2532
Office: 307 Life Sciences East
Stillwater, OK 74078
 
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Jerry R. Malayer, Ph.D.

Professor and Associate Dean for Research &
Graduate Education
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater
 
Contact Information:
Phone: (405) 744-8085
Office: Rm 222 McElroy Hall
Stillwater, OK, 74078
 
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Donald Robert McCafree, M.D.

Regents’ Professor of Medicine
Department of Medicine, Pulmonary and Critical Care
College of Medicine
University of Oklahoma Health Sciences Center- Oklahoma City
 
Contact Information:
Phone: 405-271-6173
 
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Dianne McFarlane, DVM, PhD, MS, Dip ACVIM

Professor
Physiological Sciences
Center for Veterinary Health Sciences
Oklahoma State University
Stillwater, OK

Contact Information:
Email: diannem@okstate.edu
Phone: (405) 744-2072
Office: 264 McElroy Hall
Stillwater, OK 74078

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Research Interests: 
Dr. McFarlane studies age-related neurodegeneration in horses. She focuses specifically on a debilitating condition similar to Parkinson's disease in humans.

William M. McShan, Ph.D.

Associate Professor
Department of Pharmaceutical Sciences
University of Oklahoma Health Sciences Center
Oklahoma City, Ok

Contact Information:
Email: William-McShan@ouhsc.edu
Phone: (405) 271-6593
Office: 1110 North Stonewall Ave.
CPB307
Oklahoma City, OK. 73117

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Education     Academic Appointments     Awards and Honors     Professional Memberships      Selected Publications
 

Jordan P. Metcalf, M.D.

Professor of Medicine
Virginia and Jean Rumsey Briscoe Chair in Pulmonary Diseases
Department of Medicine, Pulmonary and Critical Care
College of Medicine
University of Oklahoma Health Sciences Center- Oklahoma City
 
Contact Information:
Phone: 405-271-6173
 
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Research Interests:
The principal focus of Dr. Metcalf’s laboratory has, since its inception in 1994, been to understand on a molecular level lung immune responses to infectious agents, including adenovirus, influenza virus, and bacterial pathogens such as B. anthracis. Beginning in 2002, we developed a human lung organ culture model in order to determine how lung pathogens stimulate, and sometimes evade, the lung immune response, and also how the human host attempts to respond to the pathogen. We use primary lung cells and organ culture models to explore host-pathogen interactions with regards to adenovirus, influenza, and B. anthracis. He has also examined immunosuppressive effects of cigarette smoke in this model. Findings describing these results for all of these pathogens have been published in high-quality journals.

 

Kenneth E. Miller

Professor
Anatomy and Cell Biology
Oklahoma State University Center for Health Sciences
 
Contact Information:
Phone: 918-561-5817
Office: 1111 West 17th Street
Tulsa, OK 74107
 
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Teluguakula Narasaraju, Ph.D.

Assistant Research Professor
Department of Physiological Sciences
Center for Veterinary Health Sciences
Oklahoma State University- Stillwater

Project 4: Neutrophil-Mediated Acute Lung Injury in Influenza Virus Pneumonia

Contact:
Phone: (405) 714-3046
Office: (405) 744 8806
              Stillwater, OK 74078
 
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Antonius G.P. (Tom) Oomens, Ph.D.

Associate Professor of Virology
Department of Veterinary Pathobiology
Center for Veterinary Health Sciences
Oklahoma State University- Stillwater

Project 1: Development of an RSV Vaccine by Molecular Manipulation of the Viral Matrix Protein

Contact Information:
E-mail: oomens@okstate.edu
Phone: (405) 744-4397
Office: Rm 258 McElroy Hall
Stillwater, OK 74074

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Research Interests:
My main research interests are to understand entry and exit mechanisms of enveloped viruses and how to exploit knowledge of these mechanisms for vaccine and therapeutic purposes. Currently, my work is focussed on Respiratory Syncytial Virus (RSV), a ubiquitous and contagious paramyxovirus. Worldwide, RSV results in 200,000 deaths each year in children and yet a vaccine is not available. Through genetic manipulation of RSV, we are mapping the mechanisms underlying virus infectivity, and are creating and testing concepts for live-attenuated and virus-like-particle based RSV vaccines.

 

Marianna A. Patrauchan, Ph.D.

Assistant Professor
Department of Microbiology and Molecular Genetics
College of Arts and Sciences
Oklahoma State University- Stillwater

Contact Information:
E-mail: m.patrauchan@okstate.edu
Phone: (405) 744 8148
Office: Rm 304A Life Sciences East
Stillwater, OK 74074

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Education    Awards and Honors    Other Professional Memberships
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Research Interests:
My main research focus in on the signaling role of calcium (Ca2+) in bacterial pathogenecity. The primary model is Pseudomonas aeruginosa, a gram negative opportunistic human pathogen that is the leading cause of death in cystic fibrosis patients.
Other projects include: light regulation of Pseudomonas virulence, silver-containing antimicrobials, and geophysical properties of bacterial biofilms.

 

Mark Payton, Ph.D.

Regents Service Professor and Head
Department of Statistics
Oklahoma State University

Contact Information:
Email:  mark.payton@okstate.edu
Phone:  (405) 744-5684
Office:  MSCS 301

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Education    Academic Appointments    Recent Publications
Grants (Co-PI)     Grant (Statewide Collaborative Team)    Honors

Research Interests:
Biomedical statistics, experimental design, categorical methods

 

H. Anne Pereira, Ph.D.

Dean, Graduate College
Professor and Associate Dean for Research
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center- Oklahoma City

Contact Information:
E-mail: anne-pereira@ouhsc.edu
Phone: (405) 271-6593 ext. 58034
Office: Rm 329 College of Pharmacy Building
1110 N Stonewall, Oklahoma City, OK 73117

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Research Interests:
My area of expertise is innate immunity and inflammation in particular the role of cationic antimicrobial peptides in host defense against infection. My current research is focused on the preclinical development of a potential new class of antibiotic to treat Pseudomonas infections, the role of host defense peptides in ocular inflammation and healing, and neuroinflammation and microglial activation in Alzheimer’s disease.

 

Carey Pope, Ph.D.

Professor and Sitlington Endowed Chair in Toxicology
Department of Physiological Sciences
Center for Veterinary Health Sciences
Oklahoma State University- Stillwater

Contact Information:
E-mail: carey.pope@okstate.edu
Phone: (405) 744-6257
Office: Rm 170 McElroy Hall
Stillwater, Ok 74078

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Research Interests:
Neurotoxicology; Nanotoxicology; Autonomic Pharmacology; Mechanisms of Toxicity; Endocannabinoid Signaling; Development of Countermeasures against Organophosphate Toxicity

 

Rajagopal Ramesh, Ph.D.

Professor of Pathology,
Department of Pathology
University of Oklahoma Health Sciences Center-Oklahoma City
 
Contact Information:
Phone: 405-271-6101
Office: Suite 1403, Biomedical Research Center
              975 NE 10th St.
              Oklahoma City, OK 73104
 
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Josh Ramsey, Ph.D.

Assistant Professor of Chemical Engineering
School of Chemical Engineering
College of Engineering and Architecture
Oklahoma State University- Stillwater

Contact Information:
E-mail: josh.ramsey@okstate.edu
Phone: 405-744-5280
Office: Rm 423 Engineering North
Stillwater, OK 74078

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Research Interests:
Dr. Ramsey's lab focuses on designing nanocarriers for drug and gene delivery. Special emphasis is placed upon designing carriers that avoid immune inactivation, target specific cells, and transport the drug or gene into the target cell.

Ashish Ranjan, Ph.D.

Assistant Professor
Department of Physiological Sciences
Center for Veterinary and Health Sciences
Oklahoma State University-Stillwater

Contact Information:
E-mail: ashish.ranjan@okstate.edu
Phone: (405) 744-6292
Office: Rm 169, McElroy Hall
Stillwater, OK 74078

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Research Interests: Nanoparticle mediated image and radiation guided drug delivery
Nanotherapeutic targeting of intracellular pathogens
Nanotoxicology

 

Charles V. Rice, Ph.D.

Associate Professor
Department of Chemistry and Biochemistry
University of Oklahoma

Contact Information:
E-mail: rice@ou.edu
Phone: 405-325-5831
Office: 405-325-4811

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Research Interests:
At the University of Oklahoma, I lead a research group using NMR spectroscopy to answer questions relevant to vertical advancement in chemistry and biochemistry. These projects characterize molecular structures of both organic and inorganic materials using solid state nuclear magnetic resonance spectroscopy. We are particularly interested in changes to prokaryotic molecular structures at different stages of the organism’s life cycle. For instance, we have extensively investigated the bacterial cell wall structure and interactions of cell wall components with the microbial external environment. These studies have focused on teichoic acid polymers and peptidoglycan with the cell wall of Gram-positive bacteria, in particular the absorption of essential minerals such as calcium, magnesium, and other metal cations. This work as allowed our group to gain expertise in skills that can contribute to the proposed work: bacterial cell culture and growth curves, SEM, TEM, and Fluorescence microscopy, sterilization assessment with colony forming units (CFUs). The new models of metal chelation by the bacterial cell wall build on prior work where we provided new models describing the effect of metal ion chelation on polymer hydrogels and polymer electrolytes. As a direct logical extension of information gained from studying metal chelation in the bacterial cell wall, these data led us to consider the biochemical structures as the basis for new approaches to kill bacterial pathogens. Gram-positive bacteria use anionic teichoic acid to chelate metals and we have been able to block this process with cationic polymers that displace metal ions from the teichoic acid sites. This led to the discovery that branched poly(ethylenimine) restores β-lactam antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA). We have worked with the University of Oklahoma intellectual property office to protect our invention with a patent.

Jerry William Ritchey, Ph.D.: Immunopathology Core

Professor of Pathology
Department of Veterinary Pathobiology
Center for  Veterinary Health Sciences
Oklahoma State University-Stillwater

Contact Information:
E-mail: jerry.ritchey@okstate.edu
Phone: (405) 744-8219
Office: Rm 250 McElroy Hall
             Stillwater, OK 74078

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Research Interest:

Immunopathogenesis of infectious diseases
Pathology of the heart, lung and central nervous systems

Valentin V. Rybenkov

Associate Professor
Department of Chemistry and Biochemistry
University of Oklahoma
 
Contact Information:
E-mail: valya@ou.edu
Phone: 405-325-1677
Office: 101 Stephenson Parkway
Norman, OK 73019
 
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Edward I. Shaw, Ph.D.

Associate Professor of Microbiology & Molecular Genetics
Department of Microbiology and Molecular Genetics
College of Arts and Sciences
Oklahoma State University- Stillwater

Contact Information:
E-mail: ed.shaw@okstate.edu
Phone: 405-744-5744
Office: Rm 307 Life Sciences East
Stillwater, OK 74078

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Research Interests:
My lab is interested in the molecular interactions between obligate-intracellular bacterial pathogens and their eukaryotic host-cell. I have worked with Rickettsiae, Chlamydiae, and Coxiellae species during my career. While we are seeking to expand into Rickettsial research, our current research is focused on the obligate-intracellular bacteria, Coxiella burnetii. Of particular interest is the structure and function of
the C. burnetii type 4 Secretion System, a required virulence mechanism. We are also interested in how C. burnetii actively manipulates host cell pathways during infection. Understanding bacterial and host factors which may be involved in the invasion, intracellular trafficking, host immune-avoidance, and subsequent replication of C. burnetii in this hostile environment may lead to novel diagnostic, detection,
or intervention strategies. 

 

Jennifer H. Shaw, Ph.D.

Assistant Professor
Department of Integrative Biology
Oklahoma State University

Contact Information:
Email: jennifer.h.shaw@okstate.edu
Office Phone: (405) 744-9679
Office: 411 Life Sciences West
Oklahoma State University
Stillwater, OK  74078
Lab Website: Click here

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Research Interests:

Murine model to study Chlamydia trachomatis pathogenesis; extremophile fish model to study mitochondrial function in response to H2S 

Kenneth Michael Smith, Ph.D.

Research Assistant Member,
Arthritis and Clinical Immunology Program
Oklahoma Medical Research Foundation-Oklahoma City

Contact Information:
Phone: (405) 271-3275
Office:  Rm 5, Multiple Sclerosis Center
              825 N.E. 13th Street
              Oklahoma City, OK 73104
 
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Research Interests
Antibodies as treatment for infectious diseases; production and engineering of fully human monoclonal antibodies; anti-polysaccharides; human immune repertoires; plant secondary products as anti-infectives.

 

Timothy A. Snider, Ph.D.

Associate Professor of Pathology
Department of Veterinary Pathobiology
Center for Veterinary Health Sciences
Oklahoma State University-Stillwater
 
Contact Information:
Phone: (405) 744-0488
Office:  250 McElroy Hall
Stillwater, OK 74078
 
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Ramanjulu Sunkar, Ph.D

Assistant Professor, Department of Biochemistry and Molecular Biology,
Division of Agricultural Sciences and Natural Resources
Oklahoma State University-Stillwater
 
Contact Information:
Phone: 405-744-8496
Office: Rm 359, Noble Research Center
             Stillwater, OK 74078 
 
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Jun Wang, Ph.D., PE, CIH

Assistant Professor
Laboratory for Aerosol Exposure Science and Engineering Control
Department of Occupational & Environmental Health
College of Public Health
University of Oklahoma Health Sciences Center – Oklahoma City

Contact Information:
E-mail: jun-wang@ouhsc.edu
Website: http://laesec.org
Phone: (405)271-2070 ext. 46767
Fax: (405)271-1971
Office: Rm 425 College of Health Building
801 NE 13TH ST, Oklahoma City, OK 73104

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Research Interests:
My research interests range from studying the formation mechanism and measuring aerosol exposure in workplaces, examining the pulmonary toxicity of aerosols, developing the next generation engineering detection and control to reduce occupational inhalation exposure, and utilizing an interdisciplinary approach to solve public, environmental, and occupational health issues.

 

Robert C Welliver Sr., M.D.

Professor
Hobbs-Recknagel Chair
Chief, Section of Infectious Diseases
Department of Pediatrics
College of Medicine
University of Oklahoma Health Sciences Center- Oklahoma City

Contact Information:
E-mail: robert-welliver@ouhsc.edu
Phone: 405-271-5703

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Research Areas:
Clinic: Pediatric infectious diseases; Research: RSV and influenza virus Infections

Kevin S. Wilson, Ph.D. 

Assistant Professor
Department of Biochemistry and Molecular Biology
Oklahoma State University

Contact Information:
Email: kevin.s.wilson@okstate.edu
Phone: (405) 7446810
Office: 149 Noble Research Center
Stillwater, OK 74078

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Research Interests: 
In 2010, I spent a year as a visiting professor in Montreal, at McGill University in Professor Nahum Sonenberg’s lab. After that year, I returned to America and moved my lab to its heartland in Stillwater, Oklahoma, at Oklahoma State University. While in Alberta, my lab had developed along mechanistic themes of bacterial translation. During that decade, my interests in antibiotics and more applied research grew, partially because I was located in a medical school. My interests were also influenced by Professor Diane Taylor, a microbiologist who was studying antibiotic resistance of bacteria in my research building.
Since arriving at Oklahoma State University in 2011, I am embarking on a major new chapter in research. My new students and I are excited by how bacteria become resistant to antibiotics, especially those that target the ribosome or associated translation factors.
Our current projects originated when I was still in Alberta. A postdoctoral fellow, Nehal Thakor, worked in collaboration with Taylor’s and my lab. Nehal introduced my lab to Tet(O), a translation factor in Campylobacter jejuni that is homologous to EF-G and that confers resistance to tetracycline. This was an opportunity to study a common form of resistance of a pathogenic bacterium to an antibiotic that is widely used in medicine and agriculture.

 

Wenxin Wu, Ph.D.

Assistant Professor of Research
Department of Medicine
University of Oklahoma Health Sciences Center

Contact Information:
E-mail: Wenxin-Wu@ouhsc.edu
Phone: 405 271-1966
Office: Rm 425, URP1, 800 N. Research Pkwy.
Oklahoma City, OK 73104

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Research Interests:
My principal and long-term career goal is to develop efficient therapeutic tool for modulation of host innate immune response to pathogens, especially to influenza virus. Innate immune response is the first line of defensive strategies in human against attack of infectious agents. For most respiratory pathogens, the first local immediate response organ is lung. Two major components of the innate systems are cytokine/Chemokine defenses and cellular defenses. There is compelling evidence to suggest that cytokine and chemokine induction is important in the pathophysiology of influenza virus infection and the human response to this pathogen. Our work is to understand how cigarette smoking and secondhand smoke compromise the human innate immune system’s response to influenza virus infection, and to find novel methods to control the infection. Cigarette smoking suppresses the immune system, and smoking is a well-known major risk factor for chronic obstructive pulmonary disease and respiratory tract infections. Epidemiological studies show that influenza infection is seven times more common and is much more severe in smokers than nonsmokers. We have set up several human models and mouse models to study cigarette smoking and its effects on the innate immune system.

Lijun Xia, Ph.D.

Member and  Chair, Cardiovascular Biology Research Program
Merrick Foundation Chair in Biomedical Research
Oklahoma Medical Research Foundation- Oklahoma City.

Contact Information:
E-mail: Lijun-Xia@omrf.org
Phone: (405) 271-7892
Office:  Mail Stop 45, Room 6203 Research Tower,
825 N.E. 13th Street, Oklahoma City, OK 73104 

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Research Interests:
Glycosylation is increasingly appreciated as having a wide and yet largely unexplored spectrum of biological functions. Our published studies have identified new roles for O-glycans in blood cell trafficking, lymphatic vascular development, and intestinal inflammation. We discovered that Oglycosylation of E-selectin ligands on leukocytes, the mucins-type O-glycoprotein podoplanin on lymphatic endothelial cells, or mucins in intestinal epithelial cells are responsible for these functions. Current research focuses primarily on roles of O-glycans/specific O-glycoproteins in platelet function, vascular biology, and inflammation.

 

Xiangming Xiao, Ph.D.

Professor and Associate Director
Center for Spatial Analysis
Department of Microbiology and Plant Biology
College of Arts and Sciences
University of Oklahoma-Norman

Contact Information:
E-mail: xiangming.xiao@ou.edu
Phone: (405) 325-8941
Office: Rm 2107, Stephenson Research and Technology Center
            101 David L. Boren Blvd, Norman, OK 73019

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Research Interests:
Land use and land cover change, biogeochemical cycle, ecosystem ecology, epidemiology, disease ecology, geospatial technologies (remote sensing, GIS and GPS) and applications.

 

Noha H. Youssef

Department of Microbiology and Molecular Genetics
Department of Arts and Sciences
Oklahoma State University

Contact Information:
OSU Labs at Venture I
1110 South Innovation Way Drive
Stillwater, OK 74074
Office: (405) 744-1192
Lab: (405) 744-3193
Fax: (405) 744-1112
E-mail: noha@okstate.edu
Website: http://youssef.okstate.edu/

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Guolong Zhang, Ph.D.

Associate Professor of Molecular Immunology
Department of Animal Science
College of Agricultural Science and Natural Resources    
Oklahoma State University-Stillwater
 
Contact Information:
Phone: (405) 744-6619
Office: Rm 21, Animal Science Building
            Stillwater, OK 74078

Research Interests

Our laboratory is dedicated to delineating molecular mechanisms of innate host defense with an ultimate goal to devise more effective strategies to enhance innate immunity and disease resistance of humans and animals. Currently, we are engaged in the following lines of research:
1. Structure-activity relationship studies of novel host defense peptides (HDPs), with the goal to identify a new class of peptide antibiotics withoptimalphysiochemical properties in bacterial killing and/or immunomodulation.
2. Dietary approaches to modulate the synthesis of endogenous HDPs, with the goal to develop immune boosting dietary supplements as alternatives to antibiotics in infectious disease control.
3. Involvement of long noncoding RNAs in the pathogenesis of influenza viruses, with the goal to better understand host immune response to flu infections and possibly develop novel antivirals.