Center investigators

Gillian M. Air, Ph.D., COM, OUHSC - Phase I and II Mentor

Associate Dean, Graduate College

George Lynn Cross Research Professor
Department Biochemistry and Molecular Biology

College Medicine
University of Oklahoma Health Sciences Center

Contact Information:

Email: gillian-air@ouhsc.edu
Phone: 405-271-2085
Office: Rm 258, Library Building, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

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Research Interests:

My expertise is in molecular and biochemical aspects of influenza. Our research had two branches, one to find ways of designing better vaccines, and the second to investigate how the virus gains entry into cells and how infection might be blocked by antiviral drugs. Using monoclonal antibodies, we determined the extent and nature of epitopes on the two major surface antigens in influenza virus, hemagglutinin and neuraminidase, studying how antibodies bind to these to inhibit activity and hence virus spread, and how the virus can mutate to escape from neutralizing antibodies. We applied these results to analyze the quality as well as quantity of antibodies present in human sera after influenza vaccination and we showed that study of the fine specificities of antibodies in people who have been vaccinated or infected with influenza might predict the direction of antigenic drift, which would allow formulation of vaccines ahead of the epidemic. We were also involved in projects to design new NA inhibitors, and to identify receptors on the cell surface that facilitate virus infection with the idea of blocking that process with new drugs. It has been known for many years that the primary receptor for influenza is sialic acid, but our recent work showed that the pattern of recognition for sialic acids and their neighboring sugars is more complex than originally thought. There is year-to-year variation in the binding profile to an array of synthetic sialylated glycans. We think this is a consequence of the mutations that drive antigenic drift and that specific glycan structures are not needed for influenza infection.

Last Updated 10/23/19
Marimuthu Andiappan, Ph.D., COE, OSU - Center Investigator

Assistant Professor

Department of Chemical Engineering

Oklahoma State University

Contact:

Email: mari.andiappan@okstate.edu

Phone: 405-744-5280

Office: 420 Engineering North, Oklahoma State University, Stillwater, OK 74078

Research Interests:

Plasmonic Photocatalysis, Heterogeneous Catalysis, Homogeneous Catalysis, and Process Modeling and Simulation.
Shanjana Awasthi, Ph.D, COP, OUHSC - Phase I Project Leader

Associate Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center
University of Oklahoma

Contact Information

Email: shanjana-awasthi@ouhsc.edu

Phone: 405-271-6593 Extn: 47332

Fax: 405-271-7505
Office: Rm 324 College of Pharmacy Building, University of Oklahoma, Oklahoma City, OK 73117

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Research Interests:

Research in my lab is focused on developing immunotherapeutics and vaccines by harnessing our body's natural host defense mechanisms. Our research efforts have been focused on developing TLR4- interacting surfactant protein-A-derived peptides and dendritic cell-based vaccine approaches. We are interested in investigating the mechanism and efficacy of these approaches in vitro and in animal models of infection, inflammation and cancer.

Last Updated 10/23/19
Vibudutta Awasthi, Ph.D., CoP, OUHSC - Phase II IAC

Professor and Sandra K. & David L. Gilliland Chair in Nuclear Pharmacy

Department of Pharmaceutical Sciences

College of Pharmacy

University of Oklahoma Health Science Center

Contact Information:

Email: vibhudutta-awasthi@ouhsc.edu

Phone: 405-271-6593 x47331

Fax: 405-271-7505

Office: University of Oklahoma, Health Science Center, College of Pharmacy, Norman, OK 73019 CPB 309

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Research Interests:

My research interests are in the development of radiopharmaceuticals, small animal imaging, and the use of radiological imaging techniques to answer physiological questions. My current research focuses on the development of liposome-encapsulated hemoglobin as an artificial oxygen carrier and he is studying cerebral oxygen metabolism using positron emission tomography. I am a board-certified nuclear pharmacist with expertise in areas related to drug delivery, formulation development, nuclear pharmacy, and small animal nuclear imaging.

Last Updated 08/27/2021
Christina Bourne, Ph.D., CAS, OU-Norman - Phase II Pilot Project Leader

Assistant Professor

Department of Chemistry and Biochemistry

College of Arts and Sciences

The University of Oklahoma

Contact Information:

Email: cbourne@ou.edu

Phone: 405-325-5348

Office:

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Research Interests:

Our research interests are in the relation of protein function to macromolecular structure. We are integrating X-ray crystallography with microbiology and biochemistry to answer questions about toxin-antitoxin systems and other proteins, and their roles in bacteria that cause human disease.

Last Updated 08/27/2021
Anthony Burgett, Ph.D., CAS, OU - Phase II Pilot Project Leader

Assistant Professor

Department of Chemistry and Biochemistry

College of Arts and Sciences

The University of Oklahoma

Contact:

Email: anthony.burgett@ou.edu
Phone: 214-566-5156 (cell), 405-325-3551 (office)

Office: Rm 2060, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, Norman, OK 73019

Group Website: https://www.burgettresearchgroup.org/

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Research Interests:

Our cross-disciplinary research is focused on the molecular pharmacology and total synthesis of natural products, which are structurally complex, biologically-active molecules isolated from nature. Natural product total synthesis has long been a preeminent pursuit in organic chemistry, providing a driving force for the development of chemical reactivity and understanding. Our lab continues in this tradition, seeking to develop new approaches and new methods to achieve the synthesis of these complex structures. However, for us, the total synthesis of a natural product is a gateway and a vehicle to understanding the molecular mechanisms of action through which a compound affects biological systems. Synthesis applied to molecular pharmacology research is a uniquely powerful tool that enables full creativity and freedom to produce the natural product and derived analogs—probe analogs, analogs designed to determine the structure-activity-relations of the compound, and simplified, more-drug-like analogs. We employ, coupled to our total synthesis capabilities, a full suite of research techniques in molecular biology, protein biochemistry and cellular biology, and we seamlessly use this diverse array of methods to fully characterize the biological activity of a compound, identify its cellular target and unlock and advance any therapeutic applications.

Last Updated 10/31/2019
Josh Butcher, Ph.D., CVM, OSU - Phase II Pilot Project Leader

Assistant Professor

Department of Physiological Sciences

College of Veterinary Medicine

Oklahoma State University

Contact Information:

Email: joshua.butcher@okstate.edu
Phone: 405-744-8088
Office: Rm 168, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

I am a cardiovascular physiologist by training and have a long-standing interest in blood pressure regulation, especially in the context of the cardiometabolic dysfunction that accompanies obesity. Currently, my research looks at how manipulation of skeletal muscle (using an exercise mimetic) can attenuate the aforementioned dysfunction. We are expanding into an aging paradigm, termed sarcopenic obesity, whereby the muscle loss that accompanies obesity becomes synergistic with aging (sarcopenia). The major goal of this project is to determine the mechanistic links that drive obesity-derived cardiometabolic dysfunction; emphasizing vascular health (via characterization of endothelial and smooth muscle reactivity), the role of glucose homeostasis (Type 2 and Type 1 diabetes), oxidant stress (NOX1 and NOX4) and their organ-specific roles, and skeletal muscle fiber types.

Last Updated 10/23/19
Matthew Cabeen, Ph.D., ACS, OSU - Phase II Pilot Project Leader

Assistant Professor
Department of Microbiology and Molecular Genetics
College of Arts and Sciences
Oklahoma State University

Contact Information:
E-mail: matthew.cabeen@okstate.edu
Phone: 405-744-6652
Office: 416 LSE, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
We use advanced microfluidics and live-cell microscopy together with traditional microbiological techniques to learn how bacteria sense and respond to stress, communicate with one another, and work together to build microbial communities. We work with both the model species Bacillus subtilis and the opportunistic human pathogen Pseudomonas aeruginosa.

Last Updated 10/23/19
Rudragouda Channappanavar, Ph.D., CVM, OSU - Phase II Project Leader

Assistant Professor

Veterinary Pathobiology

College of Veterinary Medicine

Oklahoma State University

Contact Information:

Email: rchanna@okstate.edu

Phone: 405-744-7224

Office: NA

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Research Interests:

Innate and adaptive immunity, host-pathogen interactions, and molecular virology to examine the mechanistic basis for protective and pathogenic immune responses to highly virulent respiratory virus infections in young and aged hosts.

Last Updated 08/27/2021
Yong Cheng, Ph.D., DASNR, OSU - Phase II Project Leader

Assistant Professor

Department of Biochemistry and Molecular Biology

Oklahoma State University

Contact Information:

Email: ycheng@okstate.edu

Phone: 405-744-9736

Office: 354A Noble Research Center, Oklahoma State University, Stillwater OK, 74079

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Research Interests:

I am currently a tenure-track assistant professor in the Department of Biochemistry and Molecular Biology at Oklahoma State University in Stillwater, OK, and highly motivated to pursue an academic and translational-research career. I have worked on multiple projects in the field of mycobacterial pathogen-host interactions, and have interdisciplinary expertise in microbiology and immunology. I feel my qualifications are well-aligned with the studies described in this proposal. In 2007, I received my Ph.D. degree in Microbiology from Huazhong Agricultural University, China, and then I joined the University of Basel, Switzerland, with F. Hoffmann–La Roche Ltd Postdoctoral Fellowship working on the project addressing the function of M.tuberculosis protein kinase G in mycobacterial pathogenesis and the potential application of its inhibitors as new anti-TB drugs. In 2011, I joined the Dr. Jeff Schorey’s lab at the University of Notre Dame, Indiana, and focused on the research understanding the roles of exosomes in hostM.tuberculosis interactions, and potential application of these host cell-released vesicles as innovative anti-TB vaccines and biomarkers for TB diagnosis. Additionally, my studies for the first time demonstrated the engagement of the host cytosolic RNA sensing pathway in the host response to mycobacterial infections in host cells. Meanwhile, in collaboration with Hsiri Therapeutics and Dr. Marvin J. Miller from the Department of Chemistry and Biochemistry, University of Notre Dame, we identified a new family of antimycobacterial small molecules. In 2016, I was promoted to a research assistant professor at the University of Notre Dame. As an independent principle investigator, I initiated multiple projects understanding the interactions between non-tuberculous mycobacteria (NTM) and the host in cystic fibrosis (CF) patients using a cystic fibrosis murine model, aiming at development of new treatment for mycobacterial infections in cystic fibrosis patients. In Summer 2020, I was appointed as an assistant professor at Oklahoma State University. My current studies are understanding the host-pathogen interactions during M.tuberculosis and NTM infections using tissue culture and mouse models.

Last Updated 08/27/2021
Stephen Clarke, Ph.D., CoHS, OSU - Center Investigator

Associate Professor
Nutritional Sciences
College of Human Sciences
Oklahoma State University

Contact Information:
Email: stephen.clarke@okstate.edu
Phone: 405-744-2033
Office: 417 Human Sciences, Oklahoma State Univeristy, Stillwater, OK 74078

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Research Interests:
The goal of my current work is to better understand the molecular causes of symptoms associated with iron deficiency. My team is examining the microRNA profile of tissues that are central to maintaining normal iron homeostasis, and we have started to characterize the targets of iron-regulated microRNA. In slightly more applied research, I continue to collaborate with Drs. Lucas, Smith and Stoecker to assess the extent to which iron status affects an individual's risk of developing osteoporosis. Finally, more recently I have started to examine the role that iron plays in contributing to neurodegenerative diseases such as Alzheimer's or Parkinson's disease.
Mark Coggeshall, Ph.D., OMRF - Phase I and II Mentor

Robert S. Kerr, Jr. Endowed Chair

Oklahoma Medical Research Foundation

Contact Information:

E-mail: Mark-Coggeshall@omrf.org

Phone: 405-271-7209
Office: Rm S400 Chapman Bldg, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104

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Research Interests:

We investigate mechanisms leading to microvascular dysfunction, complement activation and coagulopathic responses to S. aureus and B. anthracis. We discovered the proinflammatory effects of peptidoglycan in human immune cells, identified the cells that responded and the mechanism by which they respond. The latter includes the novel finding that IgG facilitates Fc -mediated peptidoglycan phagocytosis and lysosomal digestion to create NOD ligands, and platelet activation by FcγRIIa and complement. In signaling, we were the first to show that PLCγ activation is central to lymphocyte antigen and Fc receptor signaling, that a Src-family kinase links these receptors to PLCγ activation, and that signaling events in immune cells are regulated by FcγRII recruitment of the inositol phosphatase SHIP. Our laboratory is heavily invested in phospho-flow, flow cytometry and confocal microscopy to quantitate the stimulation of intracellular events and how they are influenced by bacterial pathogens and cytokines. We showed that peptidoglycan is a common, shared, and central Gram-positive pathogen associated molecular pattern that contributes to the pathology of sepsis and that the presence of anti-peptidoglycan antibodies are needed for the responses. We discovered that peptidoglycan activates the classical complement pathway and that complement activation was removed after depletion of anti-peptidoglycan antibodies, indicating input from the classical pathway. Peptidoglycan stimulated human platelets to aggregate via platelet FcyRIIa through the peptidoglycananti-peptidoglycan immune complexes and through the complement products. In addition, we discovered the in vivo pathology caused by peptidoglycan infusion: vascular leakage, evidence of disseminated intravascular coagulation, and organ failure, all accompanied by complement deposition. I have long experience overseeing research of the type proposed here, and in guiding projects as they evolve in different directions. I have been the PI on a U19 multi-project grant focused on pathobiology of anthrax. The work involves successful and sustained collaborations with researchers in several foreign institutions, as are required by the project proposed here.

Last Updated 10/23/19
Tyrrell Conway, Ph.D., CAS, OSU - Phase II Mentor

Regents Proffessor and Head of Department
Microbiology and Molecular Genetics
College of Arts and Sciences
Oklahoma State University

Contact Information:

Email: tconway@okstate.edu
Phone: 405-820-7329

Room: 307 Life Sciences East, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

We study the physiological state of colonized bacteria in the mammalian large intestine. With NIH funding we characterize the symbiotic relationship between E. coli and anaerobes that degrade complex polysaccharides, which in turn release simple sugars to cross-feed E. coli. The major goal of this project is to determine mechanisms of nutrient competition between E. coli strains in a mouse model of intestinal colonization. In addition, we develop intuitive displays and computational environments for functional genomics data analysis.

Last Updated 10/31/19
Gabriel Cook, Ph.D., CAS, OSU - Center Investigator

Assistant Professor

Department of Chemistry

College of Arts and Sciences

Oklahoma State University

Contact Information:

Email: gabriel.cook@okstate.edu

Phone: 405-744-5941

Office: 330D Henry Bellmon Research Center, Oklahoma State University, Stillwater, OK 74078

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Last Updated 9/6/2023
Michael Scott Davis, D.V.M., Ph.D., CVM, OSU - Phase II Pilot Project Leader

Professor and Endowed Chair

Department of Physiological Sciences

College of Veterinary Medicine

Oklahoma State University

Contact Information:

E-mail: michael.davis@okstate.edu

Phone: 405-744-8172
Office: Rm 264 McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

Exercise physiology and pathophysiology, including the effects of exercise on respiratory function.

Last Updated 10/31/19
Akash Deep, Ph.D., CEAT, OSU - Center Investigator

Assistant Professor

School of Industrial Engineering and Management

College of Engineering, Architecture, and Technology

Oklahoma State University

Contact Information:
E-mail: akash.deep@okstate.edu
Office: 333 Engineering North, Oklahoma State University, Stillwater, OK 74078

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Last Updated 09/06/2023
Junpeng Deng, Ph.D., DASNR, OSU - Phase I Pilot Project Leader

Professor
Department of Biochemistry and Molecular Biology
Division of Agricultural Sciences and Natural Resources
Oklahoma State University

Contact Information:
E-mail: junpeng.deng@okstate.edu
Phone: 405-744-6192
Office: Rm 120D Henry Belmont Research Center, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

Structure-function studies on poxvirus membrane biogenesis and immune evasion. Poxviruses include some dangerous emerging or re-emerging pathogens as well as some promising vaccine vectors for infectious diseases and cancers. They are unique among viruses in that they encode a large number of proteins that are dedicated to evading host immune responses. These proteins include secreted inhibitors of cytokines as well as intracellular inhibitors of immune signaling or antiviral factors. Structure and function study on the cytokine inhibitors is one of the major aims in this lab. Enveloped viruses typically acquire their outer lipid bilayer by budding from cellular membranes, a process that is similar to the formation of cellular transport vesicles. Poxviruses, however, are unusual in that their primary envelope is not acquired by budding but through extending of open-ended crescent membranes. The origin and biogenesis of the crescent membranes are among the least understood aspects of poxvirus biology. Recent studies suggest that the crescents may derive from the endoplasmic reticulum (ER). At least five VACV proteins (A6, A11, A30.5, H7 and L2), collectively termed viral membrane assembly proteins (VMAPs) and conserved in all vertebrate poxviruses, have been found to be essential for the biogenesis of crescent membranes. VACV mutants deficient in VMAPs make viroplasms but fails to form crescents. We discovered VACV A6 as a key member of VMAPs and suggested that viral membranes are trafficked from ER to ‘viral factories’ through an active, A6-mediated process. Our recent results led us to the innovative hypotheses that A6 is a novel lipid-transfer protein (LTP) and that poxviruses obtain their primary envelope by mimicking or hijacking the cellular LTP-mediated nonvesicular lipid transport process. To our knowledge, LTP has not been previously identified in any viruses, and nonvesicular lipid transport is not known to play a role in viral replication. Detailed structure and function studies on poxvirus membrane biogenesis are currently being actively pursued.
Xufang Deng, Ph.D., CVM, OSU - Pilot Project Leader

Assistant Professor
Department of Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: xufang.deng@okstate.edu
Phone: 405-744-2158
Office: Rm 157B, McElroy Hall, Oklahoma State University, Stillwater, OK 74078
Ratnakar Deole, Ph.D., CHS, OSU - Center Investigator

Assistant Professor of Genetics

Biochemistry and Microbiology

Oklahoma State University

Contact Information:

Email: ratnakar.deole@okstate.edu

Phone: 918-525-6328

Office: West 17th Street Tulsa, OK 74104

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Research Interests:

I am a microbiologist and molecular geneticist with over 15 years’ experience working with a broad array of halophilic (salt loving) microorganisms including extremely halophilic bacteria and archaea. Since graduating from Oklahoma State University’s department of Microbiology and Molecular genetics with a PhD degree in 2011, I have carried out independent research and routinely performed research experiments involving halophiles. My lab is fully resourced and equipped to conduct the proposed research. I have trained and mentored 3 Master’s students at Northeastern State University (NSU), who graduated with a Master’s thesis after conducting research in my lab. I have also mentored and trained 50+ undergraduate students in my research laboratory and successfully authored peer reviewed publications based on some of those projects.

My graduate research involved genome based adaptation of an extremely halophilic bacteria, Halorhodospira halophila. I was involved in sequencing H. halophila and based on its genome, designed experiments to study its halophilic adaptations. I have three publications (two, first author and one, second author) based on my graduate research work. As a faculty with an independent research lab at NSU, I have successfully obtained external funds to sequence two more halophiles, H. halochloris-phylogenetic neighbor of H. halophila and an extremely halophilic cyanobacteria-Oscillatoria limnetica. For sequencing of these genomes, I have routinely collaborated with core facility services at Oklahoma State University in Stillwater. In 2018, I successfully obtained funding to incorporate halophiles in undergraduate laboratory courses at Northeastern State University to demonstrate connectivity of subjects like biochemistry, microbiology and genetics.
Yu Feng, Ph.D., CEAT, OSU - Phase I&II Pilot Project Leader

Assistant Professor
Department of Chemical Engineering
College of Engineering, Architecture, and Technology
Oklahoma State University

Contact Information:
E-mail: yu.feng@okstate.edu
Phone: 405-744-7441
Office: 420 Engineering North, Oklahoma State University, Stillwater, OK, 74078

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Research Interests:
Dr. Yu Feng joined the School of Chemical Engineering at Oklahoma State University as an Assistant Professor in August 2016. He also joined the Oklahoma Center for Respiratory and Infectious Diseases (OCRID) as an investigator. Yu Feng was a Research Assistant Professor and Lab Manager of the Computational Multi-Physics Laboratory (CM-PL) at North Carolina State University. He has also held an affiliation with DoD Biotechnology HPC Software Applications Institute (BHSAI) as a Research Scientist II. He completed his B.S. in Engineering Mechanics in 2007 from the School of Aeronautics and Astronautics, Zhejiang University, Hangzhou, China. He then joined the Department of Mechanical and Aerospace Engineering at North Carolina State University and obtained his M.S. and Ph.D. degrees in 2010 and 2013 respectively. His current research interests include advanced computational fluid-particle dynamics (CF-PD) modeling for the transport and deposition of inhalable drugs and toxicants in human respiratory systems, with applications of medical device improvements for effective and targeted drug deliveries, novel lung therapeutics, non-invasive disease diagnostic methodologies, and exposure health risk evaluations. The overall goal the research is to understand and consider more underlying physics and chemistry, in order to provide non-invasive, cost-effective, and accurate numerical tools with more simulating capabilities, complementing in vitro and in vivo studies for interdisciplinary engineering practice and academic research.

Last Updated 10/23/19
Michael J. Franklin, Ph.D., CLS, MSU - Phase II Mentor

Professor
Department of Microbiology and Immunology

College of Letters and Science
Montana State University

Contact Information:

Email: umbfm@montana.edu
Phone: 406-994-5658

Office: Cooley Laboratory 213, Montana State University, Bozeman, MT, 59715

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Research Interests:

Dr. Franklin is a Professor of Microbiology at Montana State University. Dr. Franklin’s research has focused on several aspects of Pseudomonas aeruginosa pathogenesis, primarily based on how P. aeruginosa growing in biofilms resists treatment with antibiotics and host defensive processes. His three main areas of research include: (i) the molecular genetics and biochemistry of extracellular capsular polysaccharide biosynthesis, (ii) gene expression and proteome contributions to antibiotic resistances of biofilm bacteria, (iii) physiological heterogeneity in biofilms. (I) Dr. Franklin has many years of experience studying biochemistry, molecular biology, and physical properties of P. aeruginosa extracellular polysaccharides. This work resulted in a highly cited review article in Frontiers in Microbiology, proposing models for the biosynthesis of all three secreted polysaccharides produced by P. aeruginosa. (II) Dr. Franklin’s research group has characterized physiological changes that occur when bacteria adopt a biofilm mode of growth, how these changes in gene expression and proteome patterns influence antibiotic tolerance. Work on the methodology for studying whole biofilms and biofilm cells, from his lab and from many other labs, is summarized in an invited review article in Microbiology Spectrum. (III) Dr. Franklin’s research group also pioneered strategies for analyzing physiological heterogeneities in biofilms. The research was initiated by using laser capture microdissection and transcriptomics approaches to characterize the physiologies of biofilm subpopulations. Work on the physiological heterogeneity in biofilms is summarized in a review article in Nature Reviews-Microbiology. These three research foci have led to a greater understanding of how biofilm bacteria adapt to their local microenvironments and thrive within biofilms and has led to the discovery of molecular targets for potential anti-biofilm agents.

Last Updated 10/23/19
Heather Gappa-Fahlenkamp, Ph.D., CEAT, OSU - Phase I Project Leader

Associate Professor
School of Chemical Engineering
College of Engineering and Architecture Technology
Oklahoma State University

Contact:

Email: heather.fahlenkamp@okstate.edu

Phone: 405-744-5280

Office: 423 Engineering North, Oklahoma State University, Stillwater, OK 74074

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Research Interests:

Tissue Engineering: Advanced Tissue-Equivalent Models to Study Inflammation Associated with Vascular Complications, Allergens, and Infectious Agents. Drug Delivery: Nanoparticles and Biomembranes for Controlled Delivery

Project 2- A Novel Tissue-Equivalent Respiratory Model to Study Airway Reactivity to Infectious Agents
Abhrajit Ganguly, M,D., CoM, OUHSC - Center Investigator

Assistant Professor

Department of Pediatrics

College of Medicine

Univesity of Oklahoma Health Sciences Center

Contact Information:

Email: abhrahit-ganguly@ouhsc.edu

Phone: 405-271-5215 ext. 42057

Office: OU Children's Physicians ETNP 7504, 1200 Everett Drive, Oklahoma City, OK 73104

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Research Interests:

Last Updated: 08/27/2021
Lucila Garcia-Contreras, Ph.D., COP, OUHSC - Phase II Project Leader

Associate Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center

Contact Information:
E-mail: lucila-garcia-contreras@ouhsc.edu
Phone: 405-271-6593 ext. 47205
Office: Rm 321 College of Pharmacy Building, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117

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Research Interests:

The research goal of my laboratory is “Targeted Drug Delivery” and involves the rational design of dosage forms and their in vitro evaluation, which are used to design in vivo studies. In turn, the information obtained in in vitro and in vivo studies is used to understand the underlying reasons of the performance of the dosage form with the objective of improving its formulation design to achieve the desired therapeutic effect. I am particularly interested on the design, formulation and evaluation of inhaled drugs and vaccines in powder form. For the past 12 years has focused on the designing, formulating and evaluating of drugs and vaccines delivered by the pulmonary route for local and systemic action to treat and prevent tuberculosis, and other respiratory infectious diseases. I have developed formulations for administration by the pulmonary route of a number of compounds ranging from small molecule drugs (rifampicin) to large proteins and peptides (antigen 85 and BCG). I have also been responsible for conducting studies of the pharmacokinetics and efficacy of these drugs and vaccines when delivered by the pulmonary route. Notably our pharmacokinetic and efficacy studies with capreomycin, a peptide antibiotic were the bases for Phase I clinical trials conducted by our collaborators at Harvard University. More recently, we developed an inhalable formulation to treat lung cancer and evaluated in the mouse model of adenocarcinoma. My research pulmonary drug delivery has generated interest nationally and internationally while resulting in a number of peer-reviewed articles in high impact journals, invitations to organize and speak at international conferences and consult for small pharmaceutical companies. At the OUHSC College of Pharmacy I have collaborated with other researchers in designing delivery systems and formulations for oral and vaginal administration to enhance the efficacy of their novel anti-cancer and vaccine drugs.

Last Updated 10/23/19
Darren Hagen, Ph.D., DAFS, OSU - Center Investigator

Assistant Professor

Animal Genomics

Department of Animal and Food Sciences

Oklahoma State University

Contact Information:

Email: darren.hagen@okstate.edu

Phone: 405-744-8848

Office: 311C Noble Research Center, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

The research conducted in my laboratory aims to understand biological mechanisms of gene expression and regulation using computational biology and bioinformatics tools. We are interested in understanding the role of non-coding RNAsin transcriptional regulation and post-transcriptional control of translation and especially interested in expression and epigenetic modification of tRNAs. tRNA abundance differs among tissues and life stages, having direct effects on translational efficiency and MRNA stability. We use cell culture and tissue derived from evolutionarily close livestock species. Livestock are among the best phenotype and genotype species and can offer great insight into evolution and conservation of gene regulation mechanisms. A long term goal of this line of research is to identify novel mechanisms of molecular regulation and epigenetic control of gene expression at specific times and tissues during development.
William Hildebrand, Ph.D., COM, OUHSC - Center Investigator

Professor

George Lynn Cross Professor

PHF Endowed Professor

Director, Clinical HLA Typing Laboratory

Department of Microbiology and Immunology

University of Oklahoma Health Sciences Center

Contact Information:

E-mail: William-Hildebrand@ouhsc.edu

Phone: 405-271-1203
Office: Rm 317, Stanton L Young Biomedical Research Center 975 NE 10th St, Oklahoma City, OK 73104

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Research Interests:

The Hildebrand Laboratory is focused on the major histocompatibility complex (MHC) class I and class II molecules. These molecules mediate the rejection of organ and bone marrow transplants, the targeting of cancerous and virus-infected cells for immune destruction and autoimmune responses such as diabetes and arthritis. To delineate the role that MHC molecules play in these various immune scenarios, the Hildebrand Laboratory studies MHC genes and the proteins they encode.

Last Updated 10/23/19
Myron Hinsdale, Ph.D., Animal Model Core - Core Director

Associate Professor
Department of Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: myron.hinsdale@okstate.edu
Phone: 405-744-8107
Office: Rm 264, McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

The objective for the Animal Models Core (AMC) is to ensure project experimental consistency, compliance with federal animal welfare regulations, and assistance in cutting-edge phenotyping of animal models of respiratory disease. The AMC has a wide range of phenotyping strategies in respiratory disease animal models. We are interested in developing new models that can benefit the Respiratory Center. Specifically, our research program is interested in the influences of extracellular matrix on organ homeostasis. We are concentrating on the role extracellular matrix has under disease conditions and specifically in regards to influences of ECM proteins on cell signaling. We are focusing on epithelial tissue in organs including the kidney, liver, and lung with a special interest in endothelium. Using a novel mouse model of reduced ECM proteoglycans, our studies are focused on the role that ECM proteoglycans have on the reparative response subsequent to tissue damage and disease especially in COPD and polycystic kidney disease. Our group has a broad background in pathology, animal models, and genetics, and we have extensive experience in animal surgeries and physiological assessment of metabolism.

Last Updated 10/23/19
Wouter Hoff, Ph.D., CAS, OSU - Phase I Pilot Project Leader

Associate Professor

Department of Microbiology and Molecular Genetics

College of Arts and Sciences

Oklahoma State University

Contact Information:

E-mail: wouter.hoff@okstate.edu

Phone: 405-744-4449

Office: 307 Life Sciences East, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

2013-2014 Pilot Project 4: Photoreceptors as a Novel Class Virulence Factors in Opportunistic Pathogens
Chaoqun Huang, M.D., Ph.D., CVM, OSU - Center Investigator

Associate Drector, Molecular Biology Core
Assistant Research Professor Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
Office: Rm 209A McElroy Hall, Oklahoma State University, Stillwater, OK 74078
Email: chaoqh@okstate.edu

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Research Interests:
microRNA, long non-coding RNA and Idiopathic Pulmonary Fibrosis

Last Updated 10/23/19
George Huang, Ph.D., CHS, OSU - Center Investigator

Assistant Professor

Department of Biochemistry and Microbiology

Center for Health Services

Oklahoma State University

Contact Information:

Email: george.huang@okstate.edu

Phone: 918-525-6327

Office: 100 S. Bliss Ave, Tahlequah, OK 74464

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Research Interests:

I am interested in bacterial pathogenesis with particular emphasis on the anaerobic pathogen Clostridium difficile and Fusobacterium nucleatum. C. difficile is the number one cause of antibiotic-associated diarrhea worldwide and is a public health concern due to its economic burden and patient relapses. The usage of inappropriate antibiotics disrupt the intestinal normal flora, which allows C. difficile to proliferate and damage the gut linings. In our lab we are taking a three-prong approach to combat with C. difficile infection. 1. Prevention via the development of a mucosal vaccine. 2. Offensive measures via screening for non-antibiotic antimicrobial agents. 3. Dissecting the molecular basis of toxin regulation.
Alamdar Hussian, Ph.D., COP, OUHSC - Center Investigator

Assistant Professor

Department of Pharmaceutical Sciences

College of Pharmacy

University of Oklahoma Health Sciences Center

Contact Information:

E-mail: alamdar-hussain@ouhsc.edu

Phone: 405-271-6593 ext. 47472
Office: Rm 316, College of Pharmacy Building, 1110 N Stonewall, Oklahoma City, OK 73117

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Research Interests:
Vadim Ivanov, M.D., CoM, OUHSC - Center Investigator

Assistant Professor

Assistant Medical Director of CCMH NICU

Neonatologist

Department of Pediatrics

College of Medicine

University of Oklahoma Health Science Center

Contact Information:

Email: Vadim-Ivanov@ouhsc.edu

Phone: 405-271-5215

Office: 1200 North Everett Drive, ETNP 7504 Oklahoma City, OK 73104

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Research Interests:

My research interests lie in the area of neonatology, especially in neonatal pulmonology. In particular, I am interested in meconium aspiration syndrome (MAS) – a disease that has no recognized biological mechanisms explaining the development of this severe and frequently lethal condition in neonates. The especially understudied area is the triggering mechanisms that start the cascade of events following aspiration of meconium. Through my work over the last 13 years, I have developed a novel hypothesis to account for MAS pathogenesis. The central point of this theory is that proteolytic enzymes, which originate in meconium, may be responsible for the damage observed in MAS. To test this hypothesis, I have developed an in vitro model for MAS and confirmed the role of proteolytic enzymes in MAS. I also showed that the noxious effect of these enzymes can be prevented by enzyme inhibitors. With further development, I have investigated and confirmed that the same mechanism is responsible for the destruction of surfactant protein B. The protective role of the enzyme inhibitors was also shown in this model.
Haobo Jiang, Ph.D., DASNR, OSU - Center Investigator

Regents Professor

Department of Entomology and Plant Pathology
Division of Agricultural Sciences and Natural Resources
Oklahoma State University

Contact Information:
E-mail: haobo.jiang@okstate.edu
Phone: 405-744-5527
Office: Rm 127 Noble Research Center, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
We have been investigating the molecular mechanisms of insect immune responses against pathogens that cause serious human diseases. Recognition of pathogens leads to the activation of a serine protease system in a cascade mode, which activates phenoloxidases and cytokines. Phenoloxidases generate reactive compounds to kill and sequester the invading organisms whereas cytokines trigger intracellular signaling pathways to induce the expression of antimicrobial peptides that destroy the infectious agents. We are examining the serine protease pathways and their regulation by serpins in a biochemical model insect, Manduca sexta, and trying to understand the similar system in Anopheles gambiae, the African malaria mosquito.

Last Updated 10/23/19
Clinton Jones, Ph.D., CVM, OSU - Phase II Mentor

Sitlington Professor of Infectious Diseases

Regents Professor
Department of Veterinary Pathobiology

College of Veterinary Medicine

Oklahoma State University

Contact Information:
Email: clint.jones10@okstate.edu
Phone: 405-744-1842
Office: Rm 157C McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
Susan Kovats, Ph.D., OMRF - Phase II Mentor

Associate Member

Arthritis & Clinical Immunology Research Program

Oklahoma Medical Research Foundation

Contact Information:

E-mail: Susan-Kovats@omrf.org

Phone: 405-271-8583
Office: Rm A207, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104

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Research Interests:

Tissue-resident cells of the innate immune system are the first responders upon infection or tissue damage at mucosal barrier sites. We use a murine model of influenza virus infection to understand the specific roles of lung resident dendritic cells and innate lymphocytes in antiviral responses. We also work with a tissue-engineered lung model in which human respiratory tract myeloid cells are exposed to respiratory syncytial virus, with the goal of understanding differences in neonatal and adult immunity. Our newest project will explore mechanisms by which sepsis induced by Gram-positive bacteria leads to immunosuppression.

Females often experience increased morbidity upon influenza virus infection, as well as increased incidence and severity of autoimmune disease and asthma. A major focus of the lab is to understand sex differences in numbers and function of innate type 2 lymphocytes (ILC2s) in homeostasis and upon inflammation. We published that female mice harbor significantly greater numbers of lung ILC2s in homeostasis, and we would like to understand how this sex difference contributes to ILC2 responses during infection and inflammatory disease. Ongoing projects will dissect the molecular basis of the differential regulation of female and male ILC2s by inflammatory stimuli and sex hormones in amodel of influenza virus infection. This project also will help us to understand the female predominance of autoimmune disease.

We also seek to understand how lung-resident dendritic cells (DCs) regulate T cell memory responses to influenza virus. Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual vaccination to select strains. Understanding how DCs regulate resident memory CD8+ T cells will aid the development of vaccines that elicit more universal protection to seasonal and emerging pandemic viruses. Mice lacking lung-resident IRF4-dependent DCs showed defective CD8+ T cell memory responses, and ongoing experiments will investigate IRF4-regulated pathways in DCs that promote T cell memory. Our work suggests that vaccination strategies to harness the function of IRF4-dependent DCs could promote the development of CD8+ resident memory T cells during influenza infection.

Last Updated 10/23/19
Sadagopan Krishnan (Gopan), Ph.D., CAS, OSU - Center Investigator

Associate Professor
Department of Chemistry
College of Arts and Sciences
Oklahoma State University

Contact Information:
Phone: 405-744-5946

Office: 450 Physical Sciences, Oklahoma State University, Stillwater, OK 74078
E-mail: gopan.krishnan@okstate.edu
Group Website: http://krishnangroup.okstate.edu

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Research Interests:
Clinical Biosensors, Point-of-care methods, Biocatalysis, Biomarker validation, Novel Drug-screening arrays, Bioelectrochemistry, and Biological fuel-cells.

Last Updated 10/23/19
Véronique A. Lacombe, Ph.D., D.V.M., CVM, OSU - Phase II Project Leader

Associate Professor
Department of Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: veronique.lacombe@okstate.edu
Phone: 405-744-8089
Office: Rm 283, McElroy Hall, Oklahoma State University, Stillwater, Ok 74078

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Research Interests:
Metabolism, Diabetes, Insulin resistance, Striated muscle, and Comparative medicine.
Xia Shelley Lei, Ph.D., DASNR, OSU - Phase II Pilot Project Leader

Assistant Professor
Department of Biochemistry and Molecular Biology

Division of Agricultural Sciences and Natural Resources
Oklahoma State University

Contact Information:
Email: xia.lei@okstate.edu
Phone: 405-744-2067
Office: 142F Noble Research Center, Oklahoma State University, Stillwater, OK, 74078

Last Updated: 09/06/2023
Dingbo Daniel Lin, Ph.D., CoHS, OSU - Phase I and Phase II Pilot Project Leader

Assistant Professor
Department of Nutritional Sciences
Oklahoma State University

Contact Information:
Email: dingbo.lin@okstate.edu
Phone: 405-744-5215
Fax: 405-744-1357
Office: 419 Human Sciences, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
Lin Liu, Ph.D., FAPS, CVM, OSU - Center Director/Mentor/Core Director

Regents Professor of Physiological Sciences

Lundberg-Kienlen Endowed Chair in Biomedical Research

College of Veterinary Medicine

Director, Oklahoma Center for Respiratory and Infectious Diseases

Oklahoma State University

Contact Information:

E-mail: lin.liu@okstate.edu

Phone: 405-744-4526
Office: 211 McElroy Hall, Oklahoma State University, Stillwater, OK 74078

Lab Website: https://lbtl.okstate.edu/

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Research Areas:

Influenza and bacterial infections with a focus on host-pathogen interactions, pathogenesis of pulmonary diseases (IPF, COPD, ARDS and BPD) with a focus on microRNAs and lncRNAs, and stem cell-based therapy with a focus on iPSCs and MSCs.

Last Updated 12/05/19
Pamela Lovern, Ph.D., CVM, OSU - Phase I Mentor

Associate Professor
Department of Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: pamela.lovern@okstate.edu
Phone: 405-744-9019
Fax: 405-744-8263
Office: Rm 269 McElroy Hall, Oklahoma State University OK, 74078

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Research Interests:
Regulation of arteriogenesis (collateral artery enlargement); mechanisms by which diabetes inhibits arteriogenesis; mechanisms regulating placenta growth factor (PLGF) expression; regulation of arteriogenic signaling by biomechanical forces (stretch, shear stress) and reactive oxygen species; crosstalk between VEGF family growth factors and receptors; crosstalk between pulmonary epithelial and endothelial cells; stem cell therapy for vascular repair in COPD.

Last Updated 10/23/19
Erika Lutter, Ph.D., CAS, OSU - Phase I Pilot Project Leader

Associate Professor

Department for Microbiology and Molecular Genetics

College of Arts and Sciences

Oklahoma State University

Contact Information:

Email: erika.lutter@okstate.edu

Phone: 405-744-2532

Office: 307 Life Sciences East, Oklahoma State University, Stillwater, OK 74078

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2014-2015 Pilot Project 2: Pseudomonas Aeruginosa Intra-Species Interactions

Research Interests:

Last Updated 10/23/19
Marjorie Makoni, M.D., CoM, OUHSC - Center Investigator

Assistant Professor

Department of Pediatrics

College of Medicine

University of Oklahoma Health Sciences Center

Contact Information:

Email: marjorie-makoni@ouhsc.edu

Phone: 405-5215 ext. 42181

Office: 1200 Everett Drive, ETNP 7504, 7th Floor North Pavilion, Oklahoma City 73104

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Research Interests:

Last Updated: 08/27/2021
Jerry R. Malayer, Ph.D., CVM, OSU - Phase I and Phase II IAC

Professor and Associate Dean for Research & Graduate Education

College of Veterinary Medicine

Oklahoma State University

Contact Information:

E-mail: jerry.malayer@okstate.edu

Phone: 405-744-8085
Office: Rm 222 McElroy Hall, Oklahoma State University, Stillwater, OK, 74078

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Research Interests:
Jordan P. Metcalf, M.D., COM, OUHSC - Center Co-Director/Mentor

Professor of Medicine

Virginia and Jean Rumsey Briscoe Chair in Pulmonary Diseases

Department of Medicine, Pulmonary and Critical Care

College of Medicine

University of Oklahoma Health Sciences Center

Contact Information:

E-mail: jordan-metcalf@ouhsc.edu

Phone: 405-271-6173

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Research Interests:

The principal focus of Dr. Metcalf’s laboratory has, since its inception in 1994, been to understand on a molecular level lung immune responses to infectious agents, including adenovirus, influenza virus, and bacterial pathogens such as B. anthracis. Beginning in 2002, we developed a human lung organ culture model in order to determine how lung pathogens stimulate, and sometimes evade, the lung immune response, and also how the human host attempts to respond to the pathogen. We use primary lung cells and organ culture models to explore host-pathogen interactions with regards to adenovirus, influenza, and B. anthracis. He has also examined immunosuppressive effects of cigarette smoke in this model. Findings describing these results for all of these pathogens have been published in high-quality journals.
Avishek Mitra, Ph.D., CAS, OSU - Phase II Pilot Project Leader

Assistant Professor

Department of Microbiology and Molecular Genetics

College of Arts and Sciences

Oklahoma State University

Contact Information:

Email: avi.mitra@okstate.edu

Phone: 727-480-0431

Office: 318 Life Science East, Oklahoma State University, Stillwater, OK 74075

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Research Interests:

My research interests have always involved studying bacterial pathogens. During my graduate studies I identified a novel pathway by which the alternative sigma factor, RpoN, regulates acid resistance and type III secretion systems in Escherichia coli O157:H7. Concurrently, I developed a project exploring how nonsteroidal anti-inflammatory drugs (NSAIDs) increased antibiotic resistance in Staphylococcus aureus. As a postdoctoral fellow I expanded my training and studied pathogenic mechanisms in Mycobacterium tuberculosis (Mtb), which is the causative agent of tuberculosis and the leading cause of human deaths by an infectious disease. Over the last five years my research has focused on identifying mechanisms of how Mtb acquires host iron because it is an essential nutrient for Mtb survival and virulence. For my lead project, I synthesized the toxic heme analog gallium protoporphyrin IX and used it to identify novel outer membrane components in Mtb that are essential for heme iron acquisition. This led to the discovery that the mycobacterial PPE (proline-proline-glutamate) family of proteins can function in nutrient acquisition and that some PPE proteins are channel forming outer membrane proteins. From our studies, we demonstrated that Mtb uses multiple heme uptake pathways for acquiring heme iron. The outer membrane PPE proteins and the inner membrane Dpp transporter constitute one pathway and in a second pathway heme utilization is mediated by albumin. Simultaneously, I developed a drug discovery project and by using a novel whole cell screening approach we identified molecules that inhibit siderophore dependent iron utilization in Mtb. For this project, I collaborated with Southern Research (SR) at Alabama and The GSK Open Lab in Spain and coordinated two whole-cell high throughput screening (HTS) assays and identified molecules which are currently being tested for in vivo efficacy.

One of our long-term objectives is to characterize the molecular components of the different Mtb heme uptake pathways and to eventually develop chemotherapeutic approaches that inhibit heme iron acquisition in Mtb. To this end, we will characterize how novel Mtb proteins allow Mtb to utilize heme from hemoglobin, which is the largest source of iron in the human host. We have exciting preliminary data identifying novel channel proteins and secretion systems that play a role in Mtb heme utilization. Eventually, we want to understand the true relevance of heme iron utilization in Mtb virulence and disease progression.

I have always been committed to research and education at all stages of my career. As an assistant professor at OSU, I intend to bring together a diverse group of individuals who will work together towards obtaining our long-term objectives. At the same time, I will mentor all personnel so that they can develop and pursue their own ideas. Alongside research, I will contribute to the scientific community through teaching at OSU and being part of committees that further research and education in the STEM field.

Last Updated: 08/27/2021
Sunil More Ph.D., DVM, CVM, OSU - Phase II Pilot Project Leader

Assistant Professor

Veterinary Pathobiology

Oklahoma State University

Contact Information:

Email: sunil.more@okstate.edu
Phone: 405-744-6747
Office: Rm 254, McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

The influenza virus infection is difficult to prevent in terms of the changing nature of the virus genome. The influenza virus is dependent on host factors for successful infection and replication. Our laboratory is studying the role of these host factors in the pathogenesis of influenza virus infection. In addition, influenza virus infection in a patient with COPD is very critical. Their lungs are already compromised with emphysema and bronchiolitis. Unfortunately, an animal model (cigarette smoke and elastase-induced) that closely mimics the pathology of the COPD lungs is lacking. Our laboratory is focusing on the development of this model using a different approach.

Last Updated 10/31/2019
Gaston Ofman, M.D., CoM, OUHSC - Center Investigator

Assistant Professor

Department of Pediatrics

College of Medicine

University of Oklahoma Health Science Center

Contact Information:

Email: gaston-ofman@ouhsc.edu

Phone: 786-925-7641

Office:

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Research Interests:

Last Updated: 08/27/2021
Antonius (Tom) Oomens, Ph.D., CVM, OSU - Phase I Project Leader

Associate Professor of Virology
Department of Veterinary Pathobiology
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: oomens@okstate.edu
Phone: 405-744-4397
Office: Rm 258 McElroy Hall, Oklahoma State University, Stillwater, OK 74074

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Project 1: Development of an RSV Vaccine by Molecular Manipulation of the Viral Matrix Protein

Research Interests:
My main research interests are to understand entry and exit mechanisms of enveloped viruses and how to exploit knowledge of these mechanisms for vaccine and therapeutic purposes. Currently, my work is focussed on Respiratory Syncytial Virus (RSV), a ubiquitous and contagious paramyxovirus. Worldwide, RSV results in 200,000 deaths each year in children and yet a vaccine is not available. Through genetic manipulation of RSV, we are mapping the mechanisms underlying virus infectivity, and are creating and testing concepts for live-attenuated and virus-like-particle based RSV vaccines.
Girish Patil, Ph.D., CVM, OSU - Center Investigator

Teaching Assistant Professor
Department of Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: girish.patil@okstate.edu
Phone: 405-744-8090
Office: 287, McElroy Hall, Oklahoma State University, Stillwater, OK, 74078, United States

Last Updated 09/06/2023
Marianna A. Patrauchan, Ph.D., CAS, OSU - Phase II Project Leader

Professor
Department of Microbiology and Molecular Genetics
College of Arts and Sciences
Oklahoma State University

Contact Information:
E-mail: m.patrauchan@okstate.edu
Phone: 405-744-8148
Office: Rm 304A Life Sciences East, Oklahoma State University, Stillwater, OK 74074

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Research Interests:
My main research focus in on the signaling role of calcium (Ca2+) in bacterial pathogenecity. The primary model is Pseudomonas aeruginosa, a gram negative opportunistic human pathogen that is the leading cause of death in cystic fibrosis patients.Other projects include: light regulation of Pseudomonas virulence, silver-containing antimicrobials, and geophysical properties of bacterial biofilms.

Last Updated 10/23/19
Anne H. Pereira, Ph.D. - Phase I IAC

Dean, Graduate College
Professor and Associate Dean for Research
Department of Pharmaceutical Sciences
College of Pharmacy
University of Oklahoma Health Sciences Center

Contact Information:
E-mail: anne-pereira@ouhsc.edu
Phone: 405-271-6593 ext. 58034
Office: Rm 329 College of Pharmacy Building, 1110 N Stonewall, Oklahoma City, OK 73117

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Research Interests:
My area of expertise is innate immunity and inflammation in particular the role of cationic antimicrobial peptides in host defense against infection. My current research is focused on the preclinical development of a potential new class of antibiotic to treat Pseudomonas infections, the role of host defense peptides in ocular inflammation and healing, and neuroinflammation and microglial activation in Alzheimer’s disease.
Rakhi Rajan, Ph.D, CAS, OU-Norman - Phase II Pilot Project Leader

Assistant Professor

Department of Chemistry and Biochemistry

College of Arts and Sciences

The University of Oklahoma

Contact Information:

Email: r-rajan@ou.edu

Phone: 405-325-3305

Office:

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Research Interests:

Protein-nucleic acid interactions are key to fundamental life processes such as DNA replication, transcription, recombination, and protein synthesis. Deciphering the mechanism of protein-nucleic acid interactions is invaluable for understanding human disease pathways and infections. The primary focus of my lab is to characterize protein-DNA/RNA interactions structurally, biochemically, and biophysically. The immediate emphasis is the study of the recently discovered bacterial and archaeal immune system, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). CRISPR is an RNA-based adaptive immune system that inactivates foreign DNA/RNA entering the cell, based on the sequence similarity of small RNAs, called CRISPR RNA (crRNA) to the invading genetic element. The process requires several proteins called CRISPR associated (Cas) proteins. The CRISPR/Cas9 system has revolutionized the genome editing field due to the ease with which targeted double-stranded DNA breaks can be achieved in cells, using a guide RNA and Cas9 protein. The long-term goals of my laboratory are to understand the role of CRISPR/Cas system in pathogenicity and virulence of bacteria, characterize the mechanism of adaptation of bacteria to phage infection, and to determine the signaling mechanisms of the CRISPR/Cas system. We incorporate molecular biology, biochemistry, X-ray crystallography, and additional biophysical tools to characterize these protein-nucleic acid interactions.

Last Updated: 08/27/2021
Rajagopal Ramesh, Ph.D., COM, OUHSC - Center Investigator

Professor

Department of Pathology

Jim and Christy Everest Endowed Chair in Cancer Developmental Therapeutics

Oklahoma TSET Cancer Research Scholar

Stanton L. Young Biomedical Research Center

College of Medicine

The University of Oklahoma Health Sciences Center

Contact Information:

E-mail: rajagopal-ramesh@ouhsc.edu

Phone: 405-271-6101

Laboratory: 405-271-6104

Fax: 405-271-2472
Office: Suite 1403 975 NE 10th Street, The University of Oklahoma Health Science Center, Oklahoma City, OK, 73140

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Research Interests:

Studies in my laboratory are mainly focused on novel gene-based therapeutics using viral and non-viral vectors with emphasis on translational cancer research. There are two major research areas that are actively being pursued in the laboratory. The first research area is the development and testing of non-viral and nanoparticle-based gene delivery for cancer treatment, and the second research area is studying the antitumor and anti-angiogenic properties of IL-24. Our findings have lead to Phase I clinical trials for treatment of solid tumors.

Last Updated 10/23/19
Srikanthan Ramesh, Ph.D., CEAT, OSU - Center Investigator

Assistant Professor
School of Industrial Engineering and Management
College of Engineering, Architecture, and Technology
Oklahoma State University

Contact Information:
E-mail: sri.ramesh@okstate.edu
Phone: 405-744-6055
Office: 354 Engineering North, Oklahoma State University, Stillwater, OK 74078

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Last Updated 09/06/2023
Josh Ramsey, Ph.D., CEAT, OSU - Center Investigator

Assistant Professor of Chemical Engineering
School of Chemical Engineering
College of Engineering and Architecture
Oklahoma State University

Contact Information:
E-mail: josh.ramsey@okstate.edu
Phone: 405-744-5280
Office: Rm 423 Engineering North, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
Dr. Ramsey's lab focuses on designing nanocarriers for drug and gene delivery. Special emphasis is placed upon designing carriers that avoid immune inactivation, target specific cells, and transport the drug or gene into the target cell.

Last Updated 11/06/19
Ashish Ranjan, Ph.D., CVM, OSU - Phase I Pilot Project Leader

Professor & Endowed ChairDirector: Institute for Translational and Emerging Research in Advanced Comparative Therapy (INTERACT)
Department of Physiological Sciences
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: ashish.ranjan@okstate.edu
Phone: 405-744-6292
Office: Rm 169, McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
Cancer Immunotherapy, Nanomedicine and Drug Development, and Focused Ultrasound Mediated Non-Invasive Treatments of Chronic Diseases.

Last Updated 10/23/19
Charles V. Rice, Ph.D., CAS, OU - Center Investigator

Associate Professor
Department of Chemistry and Biochemistry
University of Oklahoma

Contact Information:
E-mail: rice@ou.edu
Phone: 405-325-5831
Office:

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Research Interests:
At the University of Oklahoma, I lead a research group using NMR spectroscopy to answer questions relevant to vertical advancement in chemistry and biochemistry. These projects characterize molecular structures of both organic and inorganic materials using solid state nuclear magnetic resonance spectroscopy. We are particularly interested in changes to prokaryotic molecular structures at different stages of the organism’s life cycle. For instance, we have extensively investigated the bacterial cell wall structure and interactions of cell wall components with the microbial external environment. These studies have focused on teichoic acid polymers and peptidoglycan with the cell wall of Gram-positive bacteria, in particular the absorption of essential minerals such as calcium, magnesium, and other metal cations. This work as allowed our group to gain expertise in skills that can contribute to the proposed work: bacterial cell culture and growth curves, SEM, TEM, and Fluorescence microscopy, sterilization assessment with colony forming units (CFUs). The new models of metal chelation by the bacterial cell wall build on prior work where we provided new models describing the effect of metal ion chelation on polymer hydrogels and polymer electrolytes. As a direct logical extension of information gained from studying metal chelation in the bacterial cell wall, these data led us to consider the biochemical structures as the basis for new approaches to kill bacterial pathogens. Gram-positive bacteria use anionic teichoic acid to chelate metals and we have been able to block this process with cationic polymers that displace metal ions from the teichoic acid sites. This led to the discovery that branched poly(ethylenimine) restores β-lactam antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA). We have worked with the University of Oklahoma intellectual property office to protect our invention with a patent.
Jerry William Ritchey, Ph.D., D.V.M., - Core Director

Professor of Pathology
Department of Veterinary Pathobiology
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: jerry.ritchey@okstate.edu
Phone: 405-744-8219
Office: Rm 250 McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:

Immunopathogenesis of infectious diseases and Pathology of the heart, lungs, and central nervous systems.

Last Updated 10/23/19
Jennifer Rudd, Ph.D., CVM, OSU - Center Investigator

Assistant Professor
Department of Veterinary Pathobiology
College of Veterinary Medicine
Oklahoma State University

Contact Information:
E-mail: jennifer.rudd@okstate.edu
Phone: 405-744-5268
Office: OSU College of Veterinary Medicine, Veterinary Pathobiology, 250 McElroy Hall, Stillwater, OK, 74078
Valentin V. Rybenkov, Ph.D., CAS, OU - Phase I Pilot Project Leader

Associate Professor

Department of Chemistry and Biochemistry

College of Arts and Sciences

The University of Oklahoma

Contact Information:

E-mail: valya@ou.edu

Phone: 405-325-1677

Office: 101 Stephenson Parkway, The University of Oklahoma, Norman, OK 73019

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2013-2014 Pilot Project 1: Validation of Bacterial Condensins as Drug Targets

Research Interests:

Our current research proceeds in three directions. First, we continue mechanistic exploration of condensins with the focus on their activity within its native substrate, the chromosome. Second, we develop single DNA nanomanipulation and microfluidics methods for studies of multi-component macromolecular assemblies with complex architectures. Third, we are engaged in drug discovery studies aimed at development of new antimicrobials against currently intractable and emerging pathogens.
Susan Schroeder, Ph.D., CAS, OU - Phase II Pilot Project Leader

Associate Professor
Department of Chemistry and Biochemisty
Department of Microbiology and Plant Biology
College of Arts and Sciences

University of Oklahoma

Contact Information:
E-mail: Susan.schroeder@ou.edu
Phone: 405-744-2158
Office: 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019

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Research Interests:
My long-term research goal is to understand the fundamental physical interactions in RNA in order to predict RNA three-dimensional structures, functions, and drug targets from sequence. My lab probes structure-function relations in viral RNA and virus-host interactions using Illumina sequencing, chemical probing, nuclear magnetic resonance, crystallography, and UV optical melting, as well as a diverse array of biophysical, molecular biology, sequencing, and computational techniques.

Last Updated 10/23/19
Kenneth Michael Smith, Ph.D., OMRF - Center Investigator

Research Assistant Member
Arthritis and Clinical Immunology Program
Oklahoma Medical Research Foundation

Contact Information:

E-mail: Ken-Smith@omrf.org

Phone: 405-271-3275

Office: Rm 5, Multiple Sclerosis Center, 825 N.E. 13th Street, Oklahoma City, OK 73104

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Research Interests:

Our lab’s goal is the discovery and characterization of full length, fully human monoclonal antibodies cloned from single B cells after vaccination. We explore the use of these antibodies as novel therapeutics and diagnostics for infectious agents and also elucidate the B cell immunology which leads to these antibodies and the biology of the B cells that make them. Our primary focus is antibodies that bind to polysaccharide antigens, specifically from the Streptococcus pneumoniae (SPN) capsule. We are working to use these antibodies as novel treatments for severe pneumonia, as well as for diagnostics to both diagnose SPN infections and explore the epidemiology of SPN, for example, the distribution of antibiotic resistant and non-vaccine serotypes. We also have active projects producing and characterizing antibodies to anthrax toxins and rabies virus. We are developing new methods for characterizing monoclonal antibodies from patients with systemic lupus erythematosus. We are working to better understand the B cell immunology that leads to autoantibody production, epitope spreading and affinity maturation. We also explore aspects of general B cell immunology, including Vgene, light chain and isotype usage in immune responses to vaccination, infection, allergy and autoimmunity. Finally, we produce highly engineered antibody formats, such as bispecific antibodies and antibody-drug conjugates.
Timothy A. Snider, Ph.D., CVM, OSU - Center Investigator

Associate Professor of Pathology

Department of Veterinary Pathobiology

College of Veterinary Medicine

Oklahoma State University

Contact Information:

E-mail: tim.snider@okstate.edu

Phone: 405-744-0488

Office: 250 McElroy Hall, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
Reed Stubbendieck, Ph.D., CAS, OSU - Center Investigator

Assistant Professor

Department of Microbiology and Molecular Genetics

College of Arts and Sciences

Oklahoma State University

Contact Information:

Email: stubbendieck@okstate.edu

Phone: 405-744-7730

Office: 314 Life Science East, Oklahoma State University, Stillwater, OK, 74078

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Last Updated 09/06/2023
Trent Tipple, M.D., CoM, OUHSC - Center Investigator

Professor

Department of Pediatrics

College of Medicine

University of Oklahoma Health Sciences Center

Contact Information:

Email: trent-tipple@ouhsc.edu

Phone: 405-271-5215

Office: 1200 N Everett Dr, Children's Hospital ETNP 7504, Oklahoma City, OK, 73104

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Research Interests:

Last Updated: 08/27/2021
Rodney K. Tweten, Ph.D., CoM, OUHSC - Phase II Mentor

OU Presidentail Professor

George Lynn Cross Research Professor
Department of Microbiology and Immunology
Oklahoma University Health Sciences Center

Contact Information:
Email: Rod-Tweten@ouhsc.edu

Phone:

Office: BRC 309, Oklahoma University Health Sciences Center, Norman, OK 73104

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Research Interests:

Our research centers on the study of the mechanism of pore-forming toxins and proteins from prokaryotic and eukaryotic sources. Our studies are focused on the pore-forming mechanisms of the cholesterol dependent cytolysins (CDCs) from various pathogenic bacteria and more recently the membrane attack complex/perforin (MACPF) family of proteins that are involved in immune defense, development and pathogenesis of eukaryotic pathogens. An intriguing characteristic of these proteins is the ability of these soluble proteins to make the transition to a homo-oligomeric pore-forming complex on the membrane of eukaryotic cells. The mechanism by which they accomplish this transition is complex and each protein family contributes unique aspects to this process
Peter Vitiello, Ph.D., CoM, OUHSC - Center Investigator

Associate Professor

Department of Pediatrics

College of Medicine

University of Oklahoma Health Sciences Center

Contact Information;

Email: peter-vitiello@ouhsc.edu

Phone: 405-271-8001 ext. 41125

Office: 800 Research Parkway, Office 462. Oklahoma City, OK, 73104

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Research Interests:

Last Updated: 08/27/2021
Matthew S. Walters, Ph.D., COM, OUHSC - Center Investigator

Matthew S. Walters, Ph.D
Associate Professor of Medicine
Pulmonary, Critical Care and Sleep Medicine
Department of Medicine
University of Oklahoma Health Sciences Center

Contact Information:
E-mail: Matthew-S-Walters@ouhsc.edu
Phone: 405-271-3803
Office: 800 N. Research Parkway, Rm 410, Oklahoma City, OK 73014

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Reasearch Interests:

The major focus of my research program is to understand the cellular processes that regulate airway epithelial stem/progenitor cell fate decisions during repair and regeneration of the lung. Alterations in the normal ratio of differentiated epithelial cell types (defined as epithelial remodeling) are associated with multiple chronic lung diseases including asthma, cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). The overarching goal of my research is to identify signaling pathways that regulate differentiation of airway epithelial stem/progenitor cells into specific cell types thus providing novel targets for developing new therapies to treat chronic lung disease.In addition to studying the processes that regulate lung regeneration and repair, my lab is engaged in team-science based collaborations with Dr. James Papin (Associate Professor, Department of Pathology, Division of Comparative Medicine, OUHSC), Dr. Dean Myers (Professor and John W. Records Chair, Department of Obstetrics and Gynecology, OUHSC) and Dr. Anthony Burgett (Associate Professor, Department of Pharmaceutical Sciences, OUHSC) focused on studying host-virus interactions during respiratory virus infection (e.g., SARS-CoV-2) of the airway epithelium using both in vitro and in vivo models.

Last Updated 10/24/22
Kevin S. Wilson, Ph.D., DASNR, OSU - Phase I Project Leader

Associate Professor
Department of Biochemistry and Molecular Biology
Oklahoma State University

Contact Information:

Email: kevin.s.wilson@okstate.edu
Phone: 405-744-6810
Office: 149 Noble Research Center, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
In 2010, I spent a year as a visiting professor in Montreal, at McGill University in Professor Nahum Sonenberg’s lab. After that year, I returned to America and moved my lab to its heartland in Stillwater, Oklahoma, at Oklahoma State University. While in Alberta, my lab had developed along mechanistic themes of bacterial translation. During that decade, my interests in antibiotics and more applied research grew, partially because I was located in a medical school. My interests were also influenced by Professor Diane Taylor, a microbiologist who was studying antibiotic resistance of bacteria in my research building. Since arriving at Oklahoma State University in 2011, I am embarking on a major new chapter in research. My new students and I are excited by how bacteria become resistant to antibiotics, especially those that target the ribosome or associated translation factors. Our current projects originated when I was still in Alberta. A postdoctoral fellow, Nehal Thakor, worked in collaboration with Taylor’s and my lab. Nehal introduced my lab to Tet(O), a translation factor in Campylobacter jejuni that is homologous to EF-G and that confers resistance to tetracycline. This was an opportunity to study a common form of resistance of a pathogenic bacterium to an antibiotic that is widely used in medicine and agriculture.

Last Updated 10/23/19
Karen Wozniak, Ph.D., CAS, OSU - Phase II Pilot Project Leader

Assistant Professor
Department Microbiology and Molecular Genetics
College of Arts and Sciences
Oklahoma State University

Contact Information:
E-mail: karen.wozniak@okstate.edu
Phone: 405-744-7914
Office: 405 Life Sciences East, Oklahoma State University, Stillwater, OK 74078

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Research Interests:
Our lab is interested in studying the role of innate immune cells in protection against fungal infections, particularly their role in protection against the opportunistic fungal pathogen Cryptococcus neoformans, which is the leading cause of fungal meningitis. Our current research focuses understanding the mechanisms of interaction between C. neoformans and dendritic cells (DCs) and macrophages, and understanding their role in the initial control of this infection.

Last Updated 10/23/19
Wenxin Wu, Ph.D., COM, OUHSC - Center Investigator

Assistant Professor of Research

Department of Medicine

University of Oklahoma Health Sciences Center

Contact Information:
E-mail: Wenxin-Wu@ouhsc.edu
Phone: 405-271-1966
Office: Rm 425, URP1, 800 N. Research Pkwy., Oklahoma City, OK 73104

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Research Interests:
My principal and long-term career goal is to develop efficient therapeutic tool for modulation of host innate immune response to pathogens, especially to influenza virus. Innate immune response is the first line of defensive strategies in human against attack of infectious agents. For most respiratory pathogens, the first local immediate response organ is lung. Two major components of the innate systems are cytokine/Chemokine defenses and cellular defenses. There is compelling evidence to suggest that cytokine and chemokine induction is important in the pathophysiology of influenza virus infection and the human response to this pathogen. Our work is to understand how cigarette smoking and secondhand smoke compromise the human innate immune system’s response to influenza virus infection, and to find novel methods to control the infection. Cigarette smoking suppresses the immune system, and smoking is a well-known major risk factor for chronic obstructive pulmonary disease and respiratory tract infections. Epidemiological studies show that influenza infection is seven times more common and is much more severe in smokers than nonsmokers. We have set up several human models and mouse models to study cigarette smoking and its effects on the innate immune system.

Last Updated 10/23/19
Lijun Xia, Ph.D., OMRF - Center Investigator

Member and Program Chair, Cardiovascular Biology Research Program
Merrick Foundation Chair in Biomedical Research

Adjunct Professor, Department of Biochemistry and Molecular Biology
Oklahoma Medical Research Foundation

Contact Information:
E-mail: Lijun-Xia@omrf.org
Phone: 405-271-7892
Office: Mail Stop 45, Room 6203 Research Tower, 825 N.E. 13th Street, Oklahoma City, OK 73104

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Research Interests:

My research focuses on O-glycans, a sugar that your body makes. In my lab, we’ve found O-glycans are important in the development of the blood and lymphatic vascular system. Without this sugar, the body doesn’t know if it should grow blood vessels or pieces of the lymphatic system, or how to connect them properly. This can lead to many diseases such as cancer metastasis and fatty liver disease. We are working to understand how to prevent these potentially deadly conditions. My lab also studies the role of glycans on platelets, the smallest blood cell, in the formation of abnormal blood clots, which are the cause of common forms of heart attack and stroke. In patients with colitis and colorectal tumors, we’ve found that O-glycans are different than in patients with normal intestinal systems. So, we’re also exploring whether abnormalities of this sugar in the intestines might actually cause these diseases—in hopes of using the knowledge we gain to treat these intestinal diseases.
Xiangming Xiao, Ph.D., CAS, OU - Center Investigator

Professor and Associate Director
Center for Spatial Analysis
Department of Microbiology and Plant Biology
College of Arts and Sciences
The University of Oklahoma

Contact Information:
E-mail: xiangming.xiao@ou.edu
Phone: 405-325-8941
Office: Rm 2107, Stephenson Research and Technology Center, 101 David L. Boren Blvd, Norman, OK 73019

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Research Interests:

Applications of remote sensing and GIS in ecosystems science and natural resources; land use and cover changes; ecosystem service assessment; biogeochemistry of terrestrial ecosystems; ecosystem modeling at large spatial scales; integrated impact assessment of climate change; ecology and epidemiology of infectious diseases.
Noha H. Youssef, Ph.D., CAS, OSU - Phase I Pilot Project Leader

Department of Microbiology and Molecular Genetics
Department of Arts and Sciences
Oklahoma State University

Contact Information:
Office: OSU Labs at Venture, 1110 South Innovation Way Drive, Oklahoma State University, Stillwater, OK 74074
Office: 405-744-1192
Lab: 405-744-3193
Fax: 405-744-1112
E-mail: noha@okstate.edu
Website: http://youssef.okstate.edu

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Research Interests:
Guolong "Glenn" Zhang, Ph.D., CASNR, OSU - Center Investigator

Professor

Boulware Endowed Chair

Department of Animal and Food Sciences

Oklahoma State University

Contact Information:

E-mail: glenn.zhang@okstate.edu

Phone: 405-744-8867

Office: 212D Animal Science, Oklahoma State Unversity, Stillwater, OK 74078

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Research Interests:

Dr. Zhang is the research coordinator for our department. Dr. Zhang’s research has been focused on the manipulation of animal innate immunity and intestinal microbiota, with the long-term goal of developing novel antibiotic-free strategies to achieve optimal animal health and productivity. He has received over $6.5 million in grants to support his research while at OSU. He has authored 65 peer-reviewed publications in journals such as Science and Journal of Clinical Investigation. His papers have received nearly 6,600 citations currently with an H-index of 35.

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