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About

The broad and long term goal of the Animal Models Core is to provide consistent care, experimental procedures, and husbandry that are important to the success of projects. Each promising investigator has limited animal experimental experience, but needs to verify in vitro findings in vivo. Therefore, the Animal Model Core (AMC) will ensure project experimental consistency, compliance with federal animal welfare regulations, and effective training of project leaders and personnel in animal experimentation. Dr. Hinsdale will serve as the AMC director, and along with technical staff, will provide basic services (e.g. Colony management and husbandry, biosafety containment and housing of animals, infection of animals and harvesting of samples for analyses, and pulmonary function tests). The current experimental animal models will be mice. The four projects that are proposed require mice to further verify in vivo findings arising from the proposed in vitro experiments. In project 1, using some remarkable viral strains, BALB/c mice will be used to determine the role of the human Respiratory Syncytial Virus (RSV) Matrix protein in viral infection. In project 2, influenza infected mice will be used to validate important host factors in an innovative in vitro respiratory model. In project 3, using a novel mouse model of acute lung injury, challenged mice will be used to mechanistically explore the exciting and potential therapeutic role of a unique protein on acute bacterial lung injury. In project 4, mice will be used to determine mechanistically the pathogenic role that specific chemokine and cytokine mediators have in acute lung injury due to influenza and to determine the pioneering therapeutic combinations for ameliorating this acute lung injury. In all, the up-and-coming young investigators of this application will be breaking new ground in pulmonary disease and gaining important animal model training to prepare them for promising independent research careers.


 

  • People

    Director

    Myron Hinsdale, Ph.D, CVHS, OSUMyron Hinsdale
    Associate Professor
    Department of Physiological Sciences
    Center for Veterinary Health Sciences
    Oklahoma State University-Stillwater
     
    Contact Information:
    Phone: (405) 744-8107
    Office: Rm 264, McElroy Hall
                 Stillwater, OK 74078
    Biosketch: Dr. Hinsdale
     
     
     

    Graduate Stundent

    Nabin Poudel 
    BVSc – Tribhuvan University, Nepal
    Thesis Advisor:  Dr. Myron Hinsdale
    Research Topic:  Extracellular matrix in cell proliferation

  • Why is it important?

    Services & Equipment

    Five Modalities

    • Mouse colony management, genotyping, and husbandry
    • Animal model experiment design
    • Assistance with Vertebrate section of grant
    • Assistance with animal use protocol
    • Isolation of adipose tissue MSCs and characterization
    • Therapeutic intratracheal instillation of MSCs.
    • Viral and bacterial instillation for respiratory disease models
    • Respiratory physiology and mechanics analyses using SCIREQ flexiVent-3, Module 1
    • Blood analyzer for clinical chemistries and blood gases using i-STAT, Model i-STAT 1 IA-Abbot 
    • Real time continuous blood oxygenation analyses using MouseOx Plus, neonatal mice to adults.
    • Full anesthetic support with:
      • Vaporstick and anesthesia machine, precision vaporizer
      • Vinv-smit-0141  Rodent Induction chamber
      • Vinv-smit-0128  Rodent respiration circuit set
    • Xtreme (by Bruker) in vivo luminescent imaging with precise animal anatomic localization of mammalian and bacterial cells.

    If you have questions or would like to use any of these services please see the "Forms" tab or contact Dr. Myron Hinsdale at myron.hinsdale@okstate.edu with "AMC OCRID" in the subject line. 

  • Forms

    To utilize the services offered by the Animal Model Core please fill out this form and send it to Dr. Myron Hinsdale at myron.hinsdale@okstate.edu 

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